Machteld N. Hylkema

University of Groningen

Netherlands

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Research Interests

Cell Biology

50%

Tissue Engineering

40%

Lung Disease

30%

Prenatal Exposure

30%

Epithelial Biology

30%

Drug Metabolism

20%

Tissue Biology

20%

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Articles12

Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease

Article Link

Year:

2024

Association between 6PPD-quinone exposure and BMI, influenza, and diarrhea in children

Article Link

Year:

2024

3-D culture of human lung fibroblasts decreases proliferative and increases extracellular matrix remodeling genes

Article Link

Year:

2024

Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells

Article Link

Year:

2023

MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast–Epithelium Crosstalk

Article Link

Year:

2022

Architecture and Composition Dictate Viscoelastic Properties of Organ-Derived Extracellular Matrix Hydrogels

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Year:

2021

Ubiquitin carboxyl-terminal hydrolase isozyme L1/UCHL1 suppresses epithelial–mesenchymal transition and is under-expressed in cadmium-transformed human bronchial epithelial cells

Article Link

Year:

2021

Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring

Article Link

Year:

2020

Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring: role for AREG-induced EGFR signaling

Article Link

Year:

2020

Human lung extracellular matrix hydrogels resemble the stiffness and viscoelasticity of native lung tissue

Article Link

Year:

2020

Prenatal smoke effect on mouse offspring Igf1 promoter methylation from fetal stage to adulthood is organ and sex specific

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Year:

2020

Postnatal Smoke Exposure Further Increases the Hepatic Nicotine Metabolism in Prenatally Smoke Exposed Male Offspring and Is Linked with Aberrant Cyp2a5 Methylation

Article Link

Year:

2020

Collaborators4

Harold Snieder

NETHERLANDS

Karim Rafie

Assistant Professor

University of Groningen

NETHERLANDS

Francisco Drusso Martinez Garcia

University of Groningen

NETHERLANDS

Michael Pfaffl

Prof. of Molecular Physiolgy, Principal Invesitgator

Technical University of Munich

GERMANY

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