Manu Shankar-Hari

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University of Edinburgh

United Kingdom

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Recent Grants

Grant: Close

Early Vasopressors in Sepsis (EVIS)

Open Date: 2021-11-01

Close Date: 2025-07-31

Grant: Close

The Randomized Embedded Multifactorial Adaptive Platform Trial in Community-acquired Pneumonia (REMAP-CAP): Building an International Research Response to Variant COVID-19

Open Date: 2021-06-01

Close Date: 2022-05-31

Grant: Close

CARDINNATE: Variation in innate immune activation and cardiovascular disease risk as drivers of COVID19 outcome in South Asians in UK and India

Open Date: 2021-05-06

Close Date: 2023-05-30

Grant: Close

Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC – Multicentre evaluation Of Sodium bicarbonate in Acute kidney Injury in Critical Care)

Open Date: 2021-03-01

Close Date: 2025-12-31

Grant: Close

Sepsis Trials In Critical Care (SepTIC)

Open Date: 2020-05-01

Close Date: 2025-04-30

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Collaborators (57)

John Hurst

University College London

UNITED KINGDOM

Manu Shankar-Hari

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Recent Grants

Articles (22)

A randomized, double-blind, placebo-controlled trial of IL-7 in critically ill patients with COVID-19

Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia The REMAP-CAP Corticosteroid Domain Randomized Clinical Trial

Individual patient and donor seroprofiles in convalescent plasma treatment of COVID-19 in REMAP-CAP clinical trial

Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial

The COnfederation of REspiratory Critical Care Trials (CoReCCT): a UK research confederation

The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: a sub-investigation from the STRESS-L Randomised Study

Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID

Patient stratification using plasma cytokines and their regulators in sepsis: relationship to outcomes, treatment effect and leucocyte transcriptomic subphenotypes

Changes in Phenotypic and Molecular Features of Naïve and Central Memory T Helper Cell Subsets following SARS-CoV-2 Vaccination

Temporal Trends in Mortality of Critically Ill Patients with Sepsis in the United Kingdom, 1988–2019

Informative Subtyping of Patients with Sepsis

Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK

Airway pressure release ventilation: a survey of UK practice

Evolving Management Practices for Early Sepsis-induced Hypoperfusion: A Narrative Review

Cross-Linking Mass Spectrometry Uncovers Interactions Between High-Density Lipoproteins and the SARS-CoV-2 Spike Glycoprotein

Causal Bayesian machine learning to assess treatment effect heterogeneity by dexamethasone dose for patients with COVID-19 and severe hypoxemia

Investigation into P2Y Receptor function in platelets from patients with sepsis

Stimulation of platelet P2Y1 receptors by different endogenous nucleotides leads to functional selectivity via biased signalling

A randomised phase 2a study to investigate the effects of blocking IL-33 with tozorakimab in patients hospitalised with COVID-19: ACCORD-2

Stimulation of platelet P2Y(1) receptors by different endogenous nucleotides leads to functional selectivity via biased signalling

Elevated ferritin, mediated by IL-18 is associated with systemic inflammation and mortality in acute respiratory distress syndrome (ARDS)

Albumin versus balanced crystalloid for resuscitation in the treatment of sepsis: A protocol for a randomised controlled feasibility study, “ABC-Sepsis”

Collaborators (57)

John Hurst

Bronwen Connolly

Alasdair Corfield

Michael Llewellyn Rutter

Katie Burnham

Puja mehta

Michael Marks

Gerome Breen

Tom Wilkinson

Paul Young

Trudie Chalder

Nazir I Lone

Rebecca Coll

John Laffey

Jack Cafferkey

Michael Harhay

Claire Sharpe

Luke Daines

David R Baldwin

Theis Lange

Khondaker Miraz Rahman

Timothy Nicholson

Simon Charles Wessely

James D. Chalmers

Salman Siddiqui

Lise Estcourt

Manuel Mayr

Karen Piper Hanley

Lucy Elizabeth Mary Finnigan

Rachel Upthegrove

Matthew Semler

Louise Rose

Tamas Szakmany

Bryan Blette

Phillippa Harrison

Simon Pitchford

Gareth E Jones

Khalida Ismail

Martin Tobin

Alex Horsley

Thomas Yates

Ian Jarrold

Romit Samanta

John Pearl

ADRIAN HAYDAY

Thomas Ward

Clive Peter Page

MAURO GIACCA

Emma Claire Robinson

David Antcliffe

Amedeo Chiribiri