Manuela Lima

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Professora Catedrática (Full Professor)

University of the Azores

Portugal

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About

Manuela Lima is a Full Professor at the University of the Azores, Portugal. Her research focuses on spinocerebellar ataxia type 3 and includes investigations into genetic polymorphisms, age-dependent somatic expansions, and therapeutic efficacy of various compounds. She has contributed significantly to understanding biomarkers and the characterization of disease cohorts, enhancing research efforts related to ataxias.

Recent Grants

Grant: Close

Assessment of ataxia severity under real-life conditions with SARAhome: A multicenter study in spinocerebellar ataxia type 3 (SCA3).

Open Date: 2021-01-01

Close Date:

Grant: Close

Unconditional Grant Agreement- CC009_MJD_TRY

Open Date: 2019-01-01

Close Date: 2020-01-01

Grant: Close

Apoptosis related genes BCL-2, BAX and TP53 as biomarkers of Machado-Joseph disease.

Open Date: 2018-01-01

Close Date: 2018-01-01

Grant: Close

Discrimination of wild type and mutant ATXN3 mRNA levels by qPCR: protocol design and implementation

Open Date: 2018-01-01

Close Date: 2019-01-01

Grant: Close

Sequenciação do exoma de pares discordantes e concordantes de irmãos com ataxia espino-cerebelosa do tipo 3 (SCA3): uma ferramenta para identificar novos modificadores e investigar vias moleculares alteradas.

Open Date: 2016-06-01

Close Date: 2019-03-01

Articles (15)

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2025

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2022

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2022

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2021

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2021

Collaborators (18)

Ludger Schöls

Section head

Eberhard Karls Universität Tübingen

GERMANY

Manuela Lima

Research Interests

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About

Recent Grants

Articles (15)

Regional distribution of polymorphisms associated to the disease-causing gene of spinocerebellar ataxia type 3

Stage‐Dependent Biomarker Changes in Spinocerebellar Ataxia Type 3

Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3

Age-dependent somatic expansion of the ATXN3 CAG repeat in the blood and buccal swab DNA of individuals with spinocerebellar ataxia type 3/Machado-Joseph disease

Tissue-Specific Vulnerability to Apoptosis in Machado-Joseph Disease

Blood transcriptome sequencing identifies biomarkers able to track disease stages in spinocerebellar ataxia type 3

A standardized protocol for blood and cerebrospinal fluid collection and processing for biomarker research in ataxia

The Homogeneous Azorean Machado-Joseph Disease Cohort: Characterization and Contributions to Advances in Research

SCAview: an Intuitive Visual Approach to the Integrative Analysis of Clinical Data in Spinocerebellar Ataxias

Differential Temporal Dynamics of Axial and Appendicular Ataxia in <scp>SCA3</scp>

Tau and neurofilament light-chain as fluid biomarkers in spinocerebellar ataxia type 3

Genetic Variation in ATXN3 (Ataxin-3) 3'UTR: Insights into the Downstream Regulatory Elements of the Causative Gene of Machado-Joseph Disease/Spinocerebellar Ataxia Type 3

Novel Machado-Joseph disease-modifying genes and pathways identified by whole-exome sequencing

Polyglutamine‐Expanded Ataxin‐3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood

Characterization of Lifestyle in Spinocerebellar Ataxia Type 3 and Association with Disease Severity

Collaborators (18)

Ludger Schöls

Maria de Fátima Brilhante

Cecilia Maria Pereira Rodrigues

Daniela Vilas Boas da Silva Campos

João Vasconcelos

Joana Sousa

Jorge Sequeiros

Mercedes Prudencio

Cristina Januário

Paola Giunti

Maria do Carmo Pereira da Costa

Juliane Fluck

Conceição Bettencourt

Patricia Maciel

Anna Sulek

Jennifer Faber

Luis Pereira de Almeida

Henry Paulson

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