Patricia Maciel

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Associate Professor

University of Minho

Portugal

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About

Dr. Patricia Maciel is an Associate Professor at the University of Minho, Portugal. Her research focuses on neurodegenerative diseases, therapeutic innovations for cancer, and the genetic underpinnings of autism. Recent publications explore pharmacological interventions, computational methodologies for brain image analysis, and the physiological impact of environmental toxins on neuronal health.

Recent Grants

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Nuclear ataxin-3 protein-protein interactions as therapeutic targets in Machado-Joseph disease

Open Date: 2018-01-01

Close Date: 2022-07-01

Grant: Close

Modulation of neuronal proteostasis by serotonin: impact on neurodegeneration

Open Date: 2018-01-01

Close Date: 2022-07-01

Grant: Close

Testing the therapeutic potential of Mesenchymal Stem Cells and their secretome in an animal model of spinocerebellar ataxia type 3

Open Date: 2017-01-01

Close Date: 2017-12-01

Grant: Close

Role of glial cells in the neurodegenerative process in Machado-Joseph disease.

Open Date: 2016-01-01

Close Date: 2018-01-01

Grant: Close

Role of glial cells in the neurodegenerative process in Machado-Joseph disease.

Open Date: 2016-01-01

Close Date: 2020-01-01

Articles (20)

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2025

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2025

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, and the limited therapeutic options show poor efficacy in patients, associated to severe side effects and development of resistance.

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (18)

Cecilia Maria Pereira Rodrigues

Full Professor

Universidade de Lisboa Faculdade de Farmácia

PORTUGAL

Patricia Maciel

Research Interests

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About

Recent Grants

Articles (20)

Therapeutic Effects of Hemerocallis citrina Baroni Extract on Animal Models of Neurodegenerative Diseases Through Serotonin and HLH-30/TFEB-Dependent Mechanisms

Contribution of autosomal rare and de novo variants to sex differences in autism

<i>In vitro</i> and <i>in vivo</i> evaluation of novel chromeno[2,3-<i>d</i>]pyrimidinones as therapeutic agents for triple negative breast cancer

Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3

Pharmacological inhibition of acetylcholinesterase improves the locomotion defective phenotype of a SCA3 C. elegans model.

Differential impact of diesel exhaust particles on glutamatergic and dopaminergic neurons in Caenorhabditis elegans: A neurodegenerative perspective

<i>In vitro</i> and <i>in vivo</i> evaluation of novel chromeno[2,3-<i>d</i>]pyrimidinones as therapeutic agents for triple negative breast cancer

Computational Approaches for the Automatic Quantification of Cells from Brain Images

Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3'-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Learning the Biochemical Basis of Axonal Guidance: Using Caenorhabditis elegans as a Model

Genetic Ablation of Inositol 1,4,5-Trisphosphate Receptor Type 2 (IP3R2) Fails to Modify Disease Progression in a Mouse Model of Spinocerebellar Ataxia Type 3

Transition from Animal-Based to Human Induced Pluripotent Stem Cells (iPSCs)-Based Models of Neurodevelopmental Disorders: Opportunities and Challenges

Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3

Experimental modelling of Alzheimer's disease for therapeutic screening

Microglial Depletion Has No Impact on Disease Progression in a Mouse Model of Machado–Joseph Disease

Aripiprazole Offsets Mutant ATXN3-Induced Motor Dysfunction by Targeting Dopamine D2 and Serotonin 1A and 2A Receptors in C. elegans

Profiling Microglia in a Mouse Model of Machado&ndash;Joseph Disease

Preclinical Assessment of Mesenchymal-Stem-Cell-Based Therapies in Spinocerebellar Ataxia Type 3

Case Report: A Novel GNB1 Mutation Causes Global Developmental Delay With Intellectual Disability and Behavioral Disorders

Collaborators (18)

Cecilia Maria Pereira Rodrigues

Susana Monteiro

Daniela Vilas Boas da Silva Campos

Joana Sousa

Manuela Lima

Fernanda Marques

Perpetua Pinto-do-Ó

Kamran Khodakhah

Nuno A. Silva

Victoria Lindsay-McGee

Carina Soares‐Cunha

Sara Duarte-Silva

Marta Costa

Michael Talkowski

Nell Maltman

Andreia Teixeira-Castro

Fábio Teixeira

Bruno Fernandes

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Profiling Microglia in a Mouse Model of Machado–Joseph Disease