Marcel van Vugt

Principle Investigator/Adjunct Professor

University of Groningen

Netherlands

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Articles (13)

Year:

2024

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2024

Year:

2024

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2024

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2023

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2023

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2022

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2022

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2021

Year:

2021

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2020

Year:

2020

Year:

2020

Collaborators (6)

Jana Dobrovolna

Scientific Researcher/Deputy head of Dr. Pavel Janscak

Institute of Molecular Genetics

CZECH REPUBLIC

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Matthias Altmeyer

University of Zurich

SWITZERLAND

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Rudolf Fehrmann

Tenure track associate professor

University Medical Center Groningen

NETHERLANDS

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Anna Oravetzová

Institute of Molecular Genetics

CZECH REPUBLIC

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Marcel Tijsterman

Professor, Groupleader

Leiden University Medical Center

NETHERLANDS

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Pavel Janscak

Group Leader/Prof. Dr.

University of Zurich

SWITZERLAND

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Marcel van Vugt

Research Interests

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Articles (13)

The Fanconi anemia core complex promotes CtIP-dependent end resection to drive homologous recombination at DNA double-strand breaks

Functional ex vivoDNA fibre assay to measure replication dynamics in breast cancer tissue

FIRRM and FIGNL1: partners in the regulation of homologous recombination

cGAS-STING pathway expression correlates with genomic instability and immune cell infiltration in breast cancer

PPM1D activity promotes the replication stress caused by cyclin E1 overexpression

POLQ to the rescue for double-strand break repair during mitosis

When breaks get hot: inflammatory signaling in BRCA1/2-mutant cancers

An mRNA expression-based signature for oncogene-induced replication-stress

Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies

Improving gene function predictions using independent transcriptional components

Overexpression of Cyclin E1 or Cdc25A leads to replication stress, mitotic aberrancies, and increased sensitivity to replication checkpoint inhibitors

The RECQL helicase prevents replication fork collapse during replication stress

Cyclin E expression is associated with high levels of replication stress in triple-negative breast cancer

Collaborators (6)

Jana Dobrovolna

Matthias Altmeyer

Rudolf Fehrmann

Anna Oravetzová

Marcel Tijsterman

Pavel Janscak

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