Martin Eilers

Professor

University of Würzburg

Germany

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Professor Martin Eilers is a faculty member at the University of Würzburg, Germany. His research primarily focuses on oncogenic pathways and transcription regulation, with recent publications exploring the roles of YAP, USP11/TCEAL1 complex, eIF2B complex, and MYC in various cancers. His work contributes to the understanding of cancer stemness, immune evasion, and genome stability, emphasizing the importance of transcriptional regulation in tumor biology.

Martin Eilers

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Articles (25)

Oncogenic YAP sensitizes cells to CHK1 inhibition via CDK4/6 driven G1 acceleration

The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma.

Maintenance of p-eIF2α levels by the eIF2B complex is vital for colorectal cancer.

Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription.

Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

Immune evasion: An imperative and consequence of <scp>MYC</scp> deregulation

Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2

The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex

Regulation of BCR-mediated Ca <sup>2+</sup> mobilization by MIZ1-TMBIM4 safeguards IgG1 <sup>+</sup> GC B cell–positive selection

PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer.

NEAT1 promotes genome stability via m<sup>6</sup>A methylation-dependent regulation of CHD4.

LRP8‐mediated selenocysteine uptake is a targetable vulnerability in MYCN‐amplified neuroblastoma

USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer.

Beyond gene expression: how MYC relieves transcription stress

Crystal structure of a covalently linked Aurora-A–MYCN complex

MYC determines lineage commitment in KRAS-driven primary liver cancer development.

MYC multimers shield stalled replication forks from RNA polymerase.

MYC promotes immune-suppression in triple-negative breast cancer via inhibition of interferon signaling.

RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells.

MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts.

MYC- and MIZ1-Dependent Vesicular Transport of Double-Strand RNA Controls Immune Evasion in Pancreatic Ductal Adenocarcinoma

Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma

Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

Collaborators (19)

Matthias Dobbelstein

Marco A. Calzado

Lingling Zhang

Viktoria Haug

Ulrich Schweizer

Hermann Schindelin

Wilbert Zwart

Jeroen Bugter

Kelly Kersten

Evon Poon

Iros Barozzi

Markus E. Diefenbacher

Andreas Wack

Cornelius Schneider

José Pedro Friedmann Angeli

Hans M. Maric

Tom Grossmann

Felix Christian Eduard Vogel

Dimitrios Papadopoulos

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