Marvin Nieman

Professor

Case Western Reserve University School of Medicine

United States

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Professor Marvin Nieman is a faculty member at Case Western Reserve University School of Medicine in the United States. His research focuses on platelet biology, integrin dynamics, and biased signaling in various contexts, including cancer and cardiovascular health. He has published recent articles on topics such as protease-activated receptors and their roles in thrombosis, liver damage, and COVID-19 complications.

Articles (20)

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UNITED STATES

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Christian Yost

Professor - Neonatology

University of Utah

UNITED STATES

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Marvin Nieman

Research Interests

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Articles (20)

Elucidating the dynamics of integrin αIIbβ3 from native platelet membranes by cryo-EM with build-and-retrieve method

From theory to platelets: unraveling the history and complexities of biased signaling

Differentiating Aggressive from Nonaggressive Prostate Cancer Using Unconjugated Contrast Agents

Mice with reduced protease-activated receptor 4 reactivity show decreased venous thrombosis and platelet procoagulant activity

Hidden Power: PAR4’s Role in Liver Damage From Acetaminophen Overdose in Mice

COVID-19 Patients Putting on the Brakes with PAR1 Autoantibodies

A mouse model of the protease-activated receptor 4 Pro310Leu variant has reduced platelet reactivity

PAR2 biased signaling on the move

Glycoprotein V exerts local control of fibrin

99mTc /SPIO-loaded polymeric micelles as MRI and SPECT imaging, cancer-targeted nanoprobe for liver cancer detection

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand.

Human and mouse PAR4 are functionally distinct receptors: Studies in novel humanized mice

Plasminogen‐induced foam cell formation by macrophages occurs through a histone 2B (H2B)‐PAR1 pathway and requires integrity of clathrin‐coated pits

Complement factor C4a does not activate protease‐activated receptor 1 (PAR1) or PAR4 on human platelets

Murine cadherin‐6 mediates thrombosis in vivo in a platelet‐independent manner

Protease‐activated receptors: An illustrated review

Hemostasis vs. homeostasis: Platelets are essential for preserving vascular barrier function in the absence of injury or inflammation

PAR4 activation involves extracellular loop 3 and transmembrane residue Thr153

Collaborators (8)

Jerry Ware

Frederik Denorme

Sidney Whiteheart

Chih-Chia Su

Steven McKenzie

James V. Michael

Irina Portier

Christian Yost

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