Masayuki Amano

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Assistant professor

Kumamoto University

Japan

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About

Masayuki Amano is an Assistant Professor at Kumamoto University, Japan. His research primarily focuses on the design and synthesis of HIV-1 protease inhibitors, with significant contributions to the structural analysis of related complexes. Additionally, he investigates neutralization activity in response to various COVID-19 vaccines, including studies on the Omicron variant. His recent work encompasses the development of agents targeting HBV capsid proteins and the evaluation of novel derivatives in antiviral therapies.

Recent Grants

Grant: Close

JSPS KAKENHI Grant-in-Aid for Scientific Research (B)

Open Date: 2022-04-01

Close Date: 2025-03-01

Grant: Close

Grant-in-Aid for Scientific Research/Seeds A

Open Date: 2019-04-01

Close Date: 2020-03-01

Grant: Close

Grant for Research Development

Open Date: 2018-12-01

Close Date: 2019-12-01

Grant: Close

Grant for Scientific Research

Open Date: 2018-04-01

Close Date: 2019-03-01

Grant: Close

JSPS KAKENHI Grant-in-Aid for Scientific Research (C)

Open Date: 2018-04-01

Close Date: 2021-03-01

Articles (15)

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2022

Collaborators (4)

Johnson Agniswamy

National Institute of Allergy and Infectious Diseases

UNITED STATES

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Hiroaki Mitsuya

Kumamoto University Hospital

JAPAN

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Monika Yadav

Purdue University

UNITED STATES

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Takuya Kobayakawa

Assistant Professor

Tokyo Medical and Dental University

JAPAN

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Masayuki Amano

Research Interests

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About

Recent Grants

Articles (15)

Potent HIV‑1 protease inhibitors containing oxabicyclo octanol-derived P2-ligands: Design, synthesis, and X‑ray structural studies of inhibitor-HIV-1 protease complexes.

Neutralization activity of HCWs’ sera after Omicron XBB.1.5-adapted monovalent COVID-19 mRNA vaccination

Exploration of P1 and P4 modifications of nirmatrelvir: Design, synthesis, biological evaluation, and X-ray structural studies of SARS-CoV-2 Mpro inhibitors.

Design of substituted tetrahydrofuran derivatives for HIV-1 protease inhibitors: synthesis, biological evaluation, and X-ray structural studies

Longitudinal analysis of neutralization in sera from HCWs receiving 2 doses of Omicron BA.4/5-adapted bivalent vaccine

Comparison of neutralization activity against Omicron BA.2/BA.5 in sera from HCWs receiving heterologous/homologous COVID-19 vaccines

Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies

Development of anti-HBV agents targeting HBV capsid proteins

Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation

Neutralization against Omicron sublineages (BA.2/BA.5/BQ.1.1/XBB/XBB.1.5) in bivalent BNT162b2-vaccinated HCWs with or without risk factors, or following BT infection with Omicron

Restoration of Neutralization Activity Against Omicron BA.2 and BA.5 in Older Adults and Individuals With Risk Factors Following the Fourth Dose of Severe Acute Respiratory Syndrome Coronavirus 2 BNT162b2 Vaccine

Third-Dose BNT162b2 Vaccination Elicits Markedly High-Level SARS-CoV-2–Neutralizing Antibodies in Vaccinees Who Responded Poorly to a Second Dose in Japan

Neutralization activity of sera/IgG preparations from fully BNT162b2 vaccinated individuals against SARS-CoV-2 Alpha, Beta, Gamma, Delta, and Kappa variants.

Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands.

Fluorine Modifications Contribute to Potent Antiviral Activity against Highly Drug-Resistant HIV-1 and Favorable Blood-Brain Barrier Penetration Property of Novel Central Nervous System-Targeting HIV-1 Protease Inhibitors In Vitro

Collaborators (4)

Johnson Agniswamy

Hiroaki Mitsuya

Monika Yadav

Takuya Kobayakawa

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