Monika Yadav

Purdue University

United States

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Articles (11)

Synthesis of nirmatrelvir (paxlovid), an FDA approved SARS-COV-2 MPro inhibitor drug is described. The present optically active synthesis avoids a critical epimerization step.

Year:

2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Year:

2021

Year:

2021

Collaborators (4)

Andrew Mesecar

Distinguished Professor of Biochemistry

Purdue University

UNITED STATES

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Shinichiro Hattori

National Institute of Occupational Safety and Health, JAPAN

JAPAN

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Masayuki Amano

Assistant professor

Kumamoto University

JAPAN

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Johnson Agniswamy

National Institute of Allergy and Infectious Diseases

UNITED STATES

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Monika Yadav

Research Interests

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Articles (11)

Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19

Synthesis of optically active SARS-CoV-2 Mpro inhibitor drug nirmatrelvir (Paxlovid): an approved treatment of COVID-19

Design, Synthesis and X-Ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-Furofuran Derivatives as P2 Ligands.

Asymmetric 1,2‐Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective Synthesis of α‐Hydroxy Amides

Asymmetric 1,2-Carbamoyl Rearrangement of Lithiated Chiral Oxazolidine Carbamates and Diastereoselective Synthesis of alpha-Hydroxy Amides

Design, Synthesis and X-ray Structural Studies of Potent HIV-1 Protease Inhibitors Containing C-4 Substituted Tricyclic Hexahydro-furofuran Derivatives as P2 Ligands

Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure–Activity Relationship, and X-ray Structural Studies

Indole Chloropyridinyl Ester-Derived SARS-CoV-2 3CLpro Inhibitors: Enzyme Inhibition, Antiviral Efficacy, Structure-Activity Relationship, and X-ray Structural Studies

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors

Highly Diastereoselective Intramolecular Asymmetric Oxidopyrylium-olefin [5 + 2] Cycloaddition and Synthesis of 8-Oxabicyclo[3.2.1]oct-3-enone Containing Ring Systems

Collaborators (4)

Andrew Mesecar

Shinichiro Hattori

Masayuki Amano

Johnson Agniswamy

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