Mathias Müller

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Full Professor / Head of Institute

University of Veterinary Medicine

Austria

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About

Mathias Müller is a Full Professor and Head of Institute at the University of Veterinary Medicine in Austria. His research focuses on the JAK-STAT signaling pathway, particularly its role in immune cell regulation and responses to various pathogens, as highlighted in his recent publications. He has explored the implications of TYK2 signaling in cancer metastasis, immune homeostasis, and host resistance to infections. Through his work, Professor Müller contributes significantly to the understanding of immune responses and cellular signaling mechanisms.

Recent Grants

Grant: Close

Monarchies and Hierarchies in Shaping Chromatin Landscapes

Open Date: 2021-03-01

Close Date: 2025-02-01

Grant: Close

Monarchies and Hierarchies in Shaping Chromatin Landscapes

Open Date: 2017-03-01

Close Date: 2021-02-01

Grant: Close

Early Determinants of DNA-Virus Lytic or Latent Infection (eDEVILLI)

Open Date: 2015-04-01

Close Date: 2018-03-31

Grant: Close

Inflammation and Immunity (IAI)

Open Date: 2010-12-01

Close Date: 2019-12-01

Grant: Close

Jak-Stat Signalling from Basics to Disease

Open Date: 2006-03-01

Close Date: 2016-03-01

Mathias Müller

Research Interests

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About

Recent Grants

Articles (20)

TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis

Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions

JAK-STAT signaling maintains homeostasis in T cells and macrophages

Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia.

Lack of TYK2 signaling enhances host resistance to Candida albicans skin infection

Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification

Transcriptional Control of Interferon-Stimulated Genes.

Baseline JAK–STAT signaling maintains immune cell homeostasis

Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

JAK-Inhibitors - A Story of Success and Adverse Events.

Inducible overexpression of a FAM3C/ILEI transgene has pleiotropic effects with shortened life span, liver fibrosis and anemia in mice

Duodenal macrophages control dietary iron absorption via local degradation of transferrin

Tyk2 is a tumor suppressor in colorectal cancer

Oncogenic TYK2<sup>P760L</sup> kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade.

Stress signaling boosts interferon-induced gene transcription in macrophages

Interferons reshape the 3D conformation and accessibility of macrophage chromatin.

PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer.

Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection.

Essential role of M1 macrophages in blocking cytokine storm and pathology associated with murine HSV-1 infection

Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons

Collaborators (13)

Christina Wagner

Dietmar Herndler-Brandstetter

Manuela Baccarini

Tanja Bulat

Iros Barozzi

Birgit Strobl

Simon Arthur

Anna-Dorothea Gorki

Andreas Bergthaler

Emilio Casanova

Pavel Kovarik

Tony Tiganis

Diaaeldin I. Abdallah

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