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Melike Lakadamyali

Associate Professor

University of Pennsylvania

United States

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Research Interests

Cell Biology

100%

Biochemistry

60%

Chromatin Biology

60%

Microscopy

40%

Epigenetic

40%

Cell Imaging

30%

Stem Cell Biology

20%

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Articles20

Revealing the biophysics of lamina-associated domain formation by integrating theoretical modeling and high-resolution imaging

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Year:

2025

Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression

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Year:

2025

Heterogeneity of late endosome/lysosomes shown by multiplexed DNA-PAINT imaging

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Year:

2025

ECLiPSE: a versatile classification technique for structural and morphological analysis of 2D and 3D single-molecule localization microscopy data

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Year:

2024

Microscopy methods to visualize nuclear organization in biomechanical studies

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Year:

2024

Active transcription and epigenetic reactions synergistically regulate meso-scale genomic organization

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Year:

2024

Dissecting gene activation and chromatin remodeling dynamics in single human cells undergoing reprogramming

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Year:

2024

Toward a comprehensive view of gene architecture during transcription

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Year:

2024

Decoding the cell nucleus.

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Year:

2024

FMRP regulates MFF translation to locally direct mitochondrial fission in neurons

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Year:

2024

Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission

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Year:

2023

Interplay between stochastic enzyme activity and microtubule stability drives detyrosination enrichment on microtubule subsets

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Year:

2023

Quantitative Single-Molecule Localization Microscopy.

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Year:

2023

Actin polymerization promotes invagination of flat clathrin-coated lattices in mammalian cells by pushing at lattice edges

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Year:

2022

Aberrant chromatin reorganization in cells from diseased fibrous connective tissue in response to altered chemomechanical cues

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Year:

2022

Single nucleosome tracking to study chromatin plasticity

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Year:

2022

Technological advances in super-resolution microscopy to study cellular processes

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Year:

2022

A protocol to quantify chromatin compaction with confocal and super-resolution microscopy in cultured cells

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Year:

2021

Efficient hemogenic endothelial cell specification by RUNX1 is dependent on baseline chromatin accessibility of RUNX1-regulated TGFβ target genes

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Year:

2021

Visualizing the genome in high resolution challenges our textbook understanding

Article Link

Year:

2020

Collaborators8

Erika L.F. Holzbaur

UNITED STATES

Claudia Loebel

UNITED STATES

Shahin Rafii

Chief

Joan and Sanford I Weill Medical College of Cornell University

UNITED STATES

Rachel McCord

Associate Professor

The University of Tennessee Knoxville

UNITED STATES

Kai Tan

Professor

University of Pennsylvania

UNITED STATES

Yi-Wei Chang

Assistant Professor

University of Pennsylvania

UNITED STATES

Omar A. Quintero-Carmona

Associate Professor

University of Richmond

UNITED STATES

Qing Tang

Assistant Professor

University of Nebraska - Lincoln

UNITED STATES

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