Natalja Pustovalova Nørskov

This study investigated the impact of feeding level during the last week of gestation on performance of sows and their litters in the subsequent lactation. A total of 48 sows were assigned to one of six feeding levels (1.8, 2.4, 3.1, 3.7, 4.3, or 5.0 kg/d) from day 108 of gestation until farrowing. Post-farrowing, all sows were fed similarly during lactation with a gradual increase in feed allowance in accordance with Danish recommendation until it reached the maximum allowance of 9 kg/d on day 17 of lactation. Plasma samples were collected from the sows during farrowing and lactation, and sow’s body weight and backfat thickness, and milk samples were taken during lactation. Litters were standardized to have 13 to 15 piglets each and weighed once weekly during lactation. Plasma concentrations of urea, acetate, and butyrate in sows linearly increased (P < 0.001), while non-esterified fatty acids linearly decreased (P < 0.001) during farrowing with increasing feeding level. Moreover, concentrations of triglycerides (P < 0.001), acetate (P = 0.007), and succinate (P < 0.001) were greater in plasma collected at the onset of farrowing compared to the end of farrowing. Conversely, concentrations of glucose, urea, and butyrate (P < 0.001) were lower in plasma collected at the onset of farrowing than at the end. Sows fed 2.4 and 3.1 kg/d exhibited greater triglyceride concentrations than those fed 3.7 (P = 0.03) and 5.0 (P = 0.02) kg/d. Sows fed 1.8 kg/d during the last week of gestation had lower milk yield in wk 1 (P < 0.001) and wk 2 (P = 0.001) of lactation compared to the other groups. Additionally, litter weight gain (P = 0.04) and litter weaning weight (P = 0.007) were lower in sows fed 1.8 kg/d compared to the other groups. The greatest milk yield, litter growth, and litter size were observed in sows fed 3.7 kg/d during the last week of gestation, whereas the estimate generated by the regression model revealed that sows should have been provided with 4.0 to 4.1 kg/d as an adequate feeding level to maximize these performances in the subsequent lactation. Interestingly, feeding level during the last week of gestation did not influence feed intake during lactation. In conclusion, this study highlights the significance of adequate feed supply (4.0 to 4.1 kg/d) during the last week of gestation in order to maximize performance of sows in the subsequent lactation.

Phytoestrogens have been suggested to have an anti-proliferative role in prostate cancer, potentially by acting through estrogen receptor beta (ERβ) and modulating several hormones. We primarily aimed to investigate the effect of a phytoestrogen intervention on hormone concentrations in blood depending on the ERβ genotype. Patients with low and intermediate-risk prostate cancer, scheduled for radical prostatectomy, were randomized to an intervention group provided with soybeans and flaxseeds (∼200 mg phytoestrogens/d) added to their diet until their surgery, or a control group that was not provided with any food items. Both groups received official dietary recommendations. Blood samples were collected at baseline and endpoint and blood concentrations of different hormones and phytoestrogens were analyzed. The phytoestrogen-rich diet did not affect serum concentrations of testosterone, insulin-like growth factor 1, or sex hormone-binding globulin (SHBG). However, we found a trend of decreased risk of increased serum concentration of estradiol in the intervention group compared to the control group but only in a specific genotype of ERβ (p = 0.058). In conclusion, a high daily intake of phytoestrogen-rich foods has no major effect on hormone concentrations but may lower the concentration of estradiol in patients with prostate cancer with a specific genetic upset of ERβ.