Nicholas Spencer

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Flinders University

Australia

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Recent Grants

Grant: Close

Importance of CGRP alpha in pain processing from the large intestine

Open Date: 2016-01-01

Close Date: 2018-01-01

Grant: Close

Mechanical factors in normal human colonic motility

Open Date: 2014-01-01

Close Date: 2016-01-01

Grant: Close

Mechanisms underlying increased pain sensations during colonic inflammatory bowel disease

Open Date: 2014-01-01

Close Date: 2016-01-01

Grant: Close

Identifying sensory nerve endings that respond to painful stimuli in the upper gastrointestinal tract and determine their mechanisms of activation

Open Date: 2014-01-01

Close Date: 2016-01-01

Grant: Close

how movements of the gut activate sensory nerve cells

Open Date: 2013-01-01

Close Date: 2015-01-01

Articles (26)

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Collaborators (13)

Vladimir Zagorodnyuk

AUSTRALIA

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Stuart Brierley

Flinders University

AUSTRALIA

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Michaela Johnson

Flinders University

AUSTRALIA

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Zili Xie

Washington University in St. Louis

UNITED STATES

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Andrea Harrington

Flinders University

AUSTRALIA

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Joel Castro

Flinders University

AUSTRALIA

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Warren McNabb

Professor of Nutritional Sciences

Massey University

NEW ZEALAND

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Phaedra Spencer-Merris

Flinders University

AUSTRALIA

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Wai Ping Yew

Flinders University

AUSTRALIA

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Phil Dinning

Professor

Flinders University

AUSTRALIA

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Hongzhen Hu

Professor

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Kelsi Dodds

Flinders University

AUSTRALIA

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Xueming Hu

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Nicholas Spencer

Research Interests

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Recent Grants

Articles (26)

Extrinsic Innervation of Myenteric Plexus of Human Large Intestine Via Colonic Nerves

Gut Neuropathies and Intestinal Motility Disorders

Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force

Optogenetic activation of the gut-brain axis in freely moving mice using a fully implantable wireless battery-free device

Tetrodotoxin-resistant mechanosensitivity and L-type calcium channel-mediated spontaneous calcium activity in enteric neurons

Remote optogenetic control of the enteric nervous system and brain-gut axis in freely-behaving mice enabled by a wireless, battery-free optoelectronic device

Identification of vagal afferent nerve endings in the mouse colon and their spatial relationship with enterochromaffin cells

Mechanisms underlying the gut–brain communication

From the organ bath to the whole person

Characterization of viscerofugal neurons in human colon by retrograde tracing and multi-layer immunohistochemistry

Early Australian neuroscientists and the tyranny of distance

Peripherally Restricted Activation of Opioid Receptors Influences Anxiety-Related Behaviour and Alters Brain Gene Expression in a Sex-Specific Manner

Piezo1, but not ATP, is required for mechanotransduction by bladder mucosal afferents in cystitis

Sex-biased neural encoding of threat discrimination in nucleus accumbens afferents drives suppression of reward behavior

Novel insights into mechanisms of inhibition of colonic motility by loperamide

Stimulation of extrinsic sympathetic nerves differentially affects neurogenic motor activity in guinea pig distal colon

Types of Neurons in the Human Colonic Myenteric Plexus Identified by Multilayer Immunohistochemical Coding

Endocannabinoids, anandamide and 2-AG, regulate mechanosensitivity of mucosal afferents in the Guinea pig bladder

Slowed gastrointestinal transit is associated with an altered caecal microbiota in an aged rat model

Circadian rhythms in colonic function

The effects of loperamide on excitatory and inhibitory neuromuscular function in the human colon.

How should we define a nociceptor in the gut-brain axis?

Piezo2 channels expressed by colon-innervating TRPV1-lineage neurons mediate visceral mechanical hypersensitivity.

Quantification of CGRP-immunoreactive myenteric neurons in mouse colon.

Anatomical distribution of CGRP-containing lumbosacral spinal afferent neurons in the mouse uterine horn

Disengaging spinal afferent nerve communication with the brain in live mice

Collaborators (13)

Vladimir Zagorodnyuk

Stuart Brierley

Michaela Johnson

Zili Xie

Andrea Harrington

Joel Castro

Warren McNabb

Phaedra Spencer-Merris

Wai Ping Yew

Phil Dinning

Hongzhen Hu

Kelsi Dodds

Xueming Hu

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