Nick Devoogdt
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Articles (28)
Promising Diagnostic and Therapeutic Approaches Based on VHHs for Cancer Management
The discovery of the distinctive structure of heavy chain-only antibodies in species belonging to the Camelidae family has elicited significant interest in their variable antigen binding domain (VHH) and gained attention for various applications, such as cancer diagnosis and treatment. This article presents an overview of the characteristics, advantages, and disadvantages of VHHs as compared to conventional antibodies, and their usage in diverse applications. The singular properties of VHHs are explained, and several strategies that can augment their utility are outlined. The preclinical studies illustrating the diagnostic and therapeutic efficacy of distinct VHHs in diverse formats against solid cancers are summarized, and an overview of the clinical trials assessing VHH-based agents in oncology is provided. These investigations demonstrate the enormous potential of VHHs for medical research and healthcare.
Year:
2024
Collaborators (51)
Jens Debacker
Vrije Universiteit Brussel
Sophie Hernot
Vrije Universiteit Brussel
Niels Vandewalle
Vrije Universiteit Brussel
Katty Zeven
Vrije Universiteit Brussel
Wout De Mey
Vrije Universiteit Brussel
Cleo Goyvaerts
Vrije Universiteit Brussel
Julie Heremans
Vrije Universiteit Brussel
Catarina Xavier
Vrije Universiteit Brussel
Yannick De Vlaeminck
Vrije Universiteit Brussel
Lore Decoster
Vrije Universiteit Brussel
Tony Lahoutte
Vrije Universiteit Brussel
Geert Raes
Vrije Universiteit Brussel
Peter Covens
Vrije Universiteit Brussel
Cécile Vincke
Vrije Universiteit Brussel
Karine Breckpot
Professor
Vrije Universiteit Brussel
Noemi Declerck
Vrije Universiteit Brussel
Vicky Caveliers
Vrije Universiteit Brussel
Jessica Bridoux
Vrije Universiteit Brussel
Hannelore Ceuppens
Vrije Universiteit Brussel
Yanmeng Wang
Vrije Universiteit Brussel
Maida Živalj
Vrije Universiteit Brussel
Guillaume Courtoy
Vrije Universiteit Brussel
Tessa De Pauw
Vrije Universiteit Brussel
Robin Maximilian Awad
Vrije Universiteit Brussel
Jo Van Ginderachter
Vrije Universiteit Brussel
Ann De Becker
Vrije Universiteit Brussel
Ludwig J. Dubois
University of Maastricht
Ahmet Krasniqi
Vrije Universiteit Brussel
Laurens Raes
Vrije Universiteit Brussel
Rong Fan
Vrije Universiteit Brussel
Alexis Broisat
INSERM
Matthias D'Huyvetter
Vrije Universiteit Brussel
Sam Floru
Vrije Universiteit Brussel
Cyprine Neba Funeh
Vrije Universiteit Brussel
Janik Puttemans
Vrije Universiteit Brussel
Romina Mora Barthelmess
Vrije Universiteit Brussel
Quentin Lecocq
Vrije Universiteit Brussel
Ala Yaromina
University of Maastricht
Herlinde Dierick
Vrije Universiteit Brussel
Benoit Stijlemans
Vrije Universiteit Brussel
Marc Stroet
Vrije Universiteit Brussel
Hilde de Rooster
Ghent University
Odrade Gondry
Vrije Universiteit Brussel
Kim De Veirman
Vrije Universiteit Brussel
Fien Meeus
Vrije Universiteit Brussel
Thomas Ertveldt
Vrije Universiteit Brussel
Ana Rita Pombo Antunes
Vrije Universiteit Brussel
Timo De Groof
Research Professor
Vrije Universiteit Brussel
Matthijs Sevenois
Vrije Universiteit Brussel
Emma Verheye
Vrije Universiteit Brussel
Elke De Bruyne
Vrije Universiteit Brussel
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