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Ole Pless

Fraunhofer Institute for Translational Medicine and Pharmacology

Germany

Research Interests

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Articles (20)

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2026

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2023

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2023

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2023

Collaborators (18)

Katrin Neumann

Head of Core Facility

Technische Universität Dresden

GERMANY

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Valeria Tiranti

Faculty member

Fondazione IRCCS Istituto Neurologico Carlo Besta

ITALY

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Doron Merkler

Head of the Division of Clinical Pathology (Department of Diagnostic)

University of Geneva

SWITZERLAND

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Markus M. Rinschen

Aarhus University

DENMARK

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Manuel A Friese

Director

University Medical Center Hamburg-Eppendorf

GERMANY

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Jann Harberts

MONASH UNIVERSITY

AUSTRALIA

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Antonio del Sol

Ikerbasque Professor

LUXEMBOURG

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Jan Hahn

Subgroup Leader Laser Lab

University Medical Center Hamburg-Eppendorf

GERMANY

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Thorsten Stafforst

Professor

Eberhard Karls Universität Tübingen

GERMANY

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Dan Rujescu

Head of Clinical Division of General Psychiatry

Medical University of Vienna

AUSTRIA

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Wenli Yang

Research Assistant Professor

University of Pennsylvania

UNITED STATES

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Peter Sommer

Chief Innovation Officer

MiiCare

GERMANY

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Emma Puighermanal

Principal Investigator

Universitat Autònoma de Barcelona (UAB)

SPAIN

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Nicolas Voelcker

Professor

MONASH UNIVERSITY

AUSTRALIA

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Robert H. Blick

Professor

Deutsches Elektronen-Synchrotron DESY

GERMANY

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Pablo J. Sáez

Prof

University Medical Center Hamburg-Eppendorf

GERMANY

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Marcel Seungsu Woo

University Hospital Bonn

GERMANY

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Sereina Riniker

ETH Zurich

SWITZERLAND

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Ole Pless

Research Interests

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Articles (20)

Fast‐Track to Functional Neurons: Accessible and Minimalistic Neurogenin 2 Programming of Human iPSCs

Accelerating Leigh syndrome drug discovery through deep learning screening in brain organoids

Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease

3D Nanoprinted Structures Promote Robust Integration of Brain Organoids into Topography-Guided Neuronal Networks.

The transformative impact of stem cell core facilities in biomedical research.

Protocol for validating drug efficacy and safety in scalable 96-well platforms of human cortical organoids and melanoma brain metastases

Human organoids: Fit for drug discovery?

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy

DPP4 inhibition affects metabolism and inflammation associated pathways in hiPSC-derived steatotic HLCs

Activating PRKG1 Variant Enhances Smooth Muscle Cell Deformability To Cause Aortopathy.

Morphological profiling reveals neuroprotection via mitochondrial uncoupling in human dopaminergic neurons

Cortical organoid-derived models of the melanoma brain metastatic niche enable prioritization of cancer-targeting drugs

Linker Modification Enables Control of Key Functional Group Orientation in Macrocycles

Optimization and Evaluation of Complementary Degrader Discovery Assays for Application in Screening

The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis

Generation of two isogenic human iPSC lines (ZIPi013-B-1, ZIPi013-B-2) carrying a CRISPR/Cas9-mediated deletion of TRPM4

Identification and development of TRPM4 antagonists to counteract neuronal excitotoxicity

MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration.

Human isogenic cells of the neurovascular unit exert transcriptomic cell type-specific effects on a blood-brain barrier in vitro model of late-onset Alzheimer disease.

Generation of a set of induced pluripotent stem cell lines from two Alzheimer disease patients carrying APOE4 (MLUi007-J; MLUi008-A) and healthy old donors carrying APOE3 (MLUi009-A; MLUi010-B) to study APOE in aging and disease.

Collaborators (18)

Katrin Neumann

Valeria Tiranti

Doron Merkler

Markus M. Rinschen

Manuel A Friese

Jann Harberts

Antonio del Sol

Jan Hahn

Thorsten Stafforst

Dan Rujescu

Wenli Yang

Peter Sommer

Emma Puighermanal

Nicolas Voelcker

Robert H. Blick

Pablo J. Sáez

Marcel Seungsu Woo

Sereina Riniker

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