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Richard E Lee

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Member

St. Jude Children's Research Hospital

United States

Research Interests

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Recent Grants

Grant: Open

Advancing Pantothenate Kinase Activation Therapy

Open Date: 2025-09-01

Close Date: 2030-05-31

Grant: Open

Hybrid Antibiotics for Persistent Infections

Open Date: 2023-09-26

Close Date: 2028-07-31

Grant: Open

Targeting NuoD for the treatment of H. pylori

Open Date: 2023-05-01

Close Date: 2028-04-30

Grant: Close

Molecular elucidation of the Francisella tularensis virulence mechanism

Open Date: 2021-05-21

Close Date: 2026-04-30

Grant: Close

Spectinomycin analogs for NTM infections

Open Date: 2020-09-17

Close Date: 2025-08-31

Articles (18)

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2023

Collaborators (17)

Daniel Harki

Professor

University of Minnesota

UNITED STATES

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Mary Jackson

Colorado State University

UNITED STATES

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Brenda Schulman

Director

Max Planck Institute of Biochemistry

GERMANY

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Gregory T. Robertson

Colorado State University

UNITED STATES

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mercedes gonzalez-juarrero

Professor

Colorado State University

UNITED STATES

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Sven N. Hobbie

University of Zurich

SWITZERLAND

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Eunjeong Shin

Case Western Reserve University

UNITED STATES

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James MacRae

Head of metabolomics

The Francis Crick Institute

UNITED KINGDOM

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Monika Kumaraswamy

Associate Professor of Medicine

The University of Texas at Tyler

UNITED STATES

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Robert Gray

Clinical Lecturer

University College London

UNITED KINGDOM

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Ingo Wohlgemuth

Project Group Leader

Max Planck Institute for Multidisciplinary Sciences

GERMANY

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Clifford Gee

Assistant Professor

Creighton University

UNITED STATES

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Jason Rosch

Member

St. Jude Children's Research Hospital

UNITED STATES

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Bernd Meibohm

University of Tennessee Health Science Center

UNITED STATES

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Ha Won Lee

Senior Scientist

St. Jude Children's Research Hospital

UNITED STATES

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Taosheng Chen

Full Member

St. Jude Children's Research Hospital

UNITED STATES

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Markus Weingarth

Utrecht University

NETHERLANDS

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Richard E Lee

Research Interests

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Recent Grants

Articles (18)

Sterilizing activity of spectinamide MBX-4888A when replacing linezolid in the Nix-TB regimen in the relapsing BALB/c mouse model of tuberculosis

Characterization of new mouse models of acute and chronic Mycobacterium abscessus infection for antimicrobial drug screening

Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways

Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids.

Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus.

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria.

Comprehensive stability analysis of 13 β-lactams and β-lactamase inhibitors in <i>in vitro</i> media, and novel supplement dosing strategy to mitigate thermal drug degradation

Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in <i>Mycobacterium</i> abscessus

Sophisticated natural products as antibiotics

Synthesis and antibacterial action of 3’,6’-disubstituted spectinomycins

Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2

Development of tetracycline analogues with increased aqueous stability for the treatment of mycobacterial infections.

Development of Brain Penetrant Pyridazine Pantothenate Kinase Activators.

The small molecule CBR-5884 inhibits the <i>Candida albicans</i> phosphatidylserine synthase.

Pantothenate Kinase Activation Restores Brain Coenzyme A in a Mouse Model of Pantothenate Kinase-Associated Neurodegeneration.

Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics

Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors

E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.

Collaborators (17)

Daniel Harki

Mary Jackson

Brenda Schulman

Gregory T. Robertson

mercedes gonzalez-juarrero

Sven N. Hobbie

Eunjeong Shin

James MacRae

Monika Kumaraswamy

Robert Gray

Ingo Wohlgemuth

Clifford Gee

Jason Rosch

Bernd Meibohm

Ha Won Lee

Taosheng Chen

Markus Weingarth

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