Ruben Bierings

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Netherlands

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Recent Grants

Grant: Close

New determinant of Weibel-Palade body shape and Von Willebrand factor trafficking within ER-Golgi SNARE networks

Open Date: 2021-01-01

Close Date: 2025-01-01

Grant: Close

Personalized gene-targeted treatment strategies for the management of the complex genetic bleeding disorder Von Willebrand Disease in stratified patient populations

Open Date: 2021-01-01

Close Date: 2025-01-01

Grant: Close

SYMPHONY:Orchestrating personalised treatment for patients with bleeding disorders

Open Date: 2020-01-01

Close Date: 2025-01-01

Grant: Close

Von Willebrand factor secretion from Weibel-Palade bodies: pulling the strings in vascular disease

Open Date: 2018-01-01

Close Date: 2023-01-01

Grant: Close

The only way is up: polarized secretion of VWF and tethering by adhesion molecules

Open Date: 2017-01-01

Close Date: 2021-01-01

Articles (20)

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Collaborators (11)

Karina Meijer

University Medical Center Groningen

NETHERLANDS

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Judith Klumperman

University Medical Center Groningen

NETHERLANDS

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James Dahlman

Associate Professor

Emory University School of Medicine

UNITED STATES

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Cecile Denis

INSERM

FRANCE

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James Streetley

University of Glasgow

UNITED KINGDOM

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Frank Leebeek

Erasmus University Rotterdam

NETHERLANDS

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Rolf Urbanus

Associate professor

University Medical Center Groningen

NETHERLANDS

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Coen Maas

Associate professor

University Medical Center Groningen

NETHERLANDS

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Tom Carter

UNITED KINGDOM

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Alistair Hume

Assistant Professor

University of Nottingham

UNITED KINGDOM

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Moniek de Maat

Professor of Biochemistry of Haemostasis and Thrombosis

Erasmus MC

NETHERLANDS

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Ruben Bierings

Research Interests

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Recent Grants

Articles (20)

Amelioration of a von Willebrand disease type 2B phenotype in vivo upon treatment with allele-selective siRNAs

Von Willebrand disease-specific defects and proteomic signatures in endothelial colony forming cells

DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis

Proteomic analysis indicates lower abundance of platelet α-granule proteins in Glanzmann thrombasthenia

A rapid whole-blood adenosine triphosphate secretion test can be used to exclude platelet-dense granule deficiency

The severe von Willebrand disease variant p.M771V leads to impaired anterograde trafficking of von Willebrand factor in patient-derived and base-edited endothelial colony-forming cells

Endothelial colony-forming cells in the spotlight

Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Transcriptional and functional profiling identifies inflammation and endothelial-to-mesenchymal transition as potential drivers for phenotypic heterogeneity within a cohort of endothelial colony forming cells

Variant mapping using mass spectrometry–based proteotyping as a diagnostic tool in von Willebrand disease

Altered Storage and Function of von Willebrand Factor in Human Cardiac Microvascular Endothelial Cells Isolated from Recipient Transplant Hearts

Automated segmentation and quantitative analysis of organelle morphology, localization and content using CellProfiler

CSI: Weibel-Palade bodies

Mutations in Neurobeachin-like 2 do not impact Weibel-Palade body biogenesis and von Willebrand factor secretion in gray platelet syndrome Endothelial Colony Forming Cells

Lupus anticoagulant associates with thrombosis in patients with COVID-19 admitted to intensive care units: A retrospective cohort study

SYMPHONY consortium: Orchestrating personalized treatment for patients with bleeding disorders

Dispatch and delivery at the ER–Golgi interface: how endothelial cells tune their hemostatic response

Syntaxin 5 determines Weibel-Palade body size and Von Willebrand factor secretion by controlling Golgi architecture.

GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies

Quantitative 3D microscopy highlights altered von Willebrand factor α‐granule storage in patients with von Willebrand disease with distinct pathogenic mechanisms

Collaborators (11)

Karina Meijer

Judith Klumperman

James Dahlman

Cecile Denis

James Streetley

Frank Leebeek

Rolf Urbanus

Coen Maas

Tom Carter

Alistair Hume

Moniek de Maat

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