Takehiko Sasaki

Professor

Tokyo Medical and Dental University

Japan

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About

Takehiko Sasaki is a Professor at Tokyo Medical and Dental University in Japan. His research focuses on the regulation of phosphoinositides, cellular lipid homeostasis, and the molecular mechanisms underlying adipocyte development and cancer progression. Recent articles by Professor Sasaki explore topics such as transdifferentiation in adrenal lipoma formation, lysosomal ionic homeostasis, and the implications of electrical signals in spermatozoa.

Articles (17)

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2025

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2025

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2025

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2025

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2025

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2025

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2024

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2022

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

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2020

Collaborators (16)

Haruhiko Miyata

Osaka University

JAPAN

Takehiko Sasaki

Research Interests

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Articles (17)

Control of Golgi- V-ATPase through Sac1-dependent co-regulation of PI(4)P and cholesterol

Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2

PI5P4K inhibitors: promising opportunities and challenges

Definition of phosphatidylinositol 4,5-bisphosphate distribution by freeze-fracture replica labeling

MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes

Adrenal lipoma formation via PI(3,4,5)P 3 /AKT-dependent transdifferentiation of adrenocortical cells into adipocytes

The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase

N‐(3,4‐dimethoxyphenethyl)‐6‐methyl‐2,3,4,9‐tetrahydro‐1H‐carbazol‐1‐amine inhibits bladder cancer progression by suppressing YAP1/TAZ

A mass spectrometric method for in-depth profiling of phosphoinositide regioisomers and their disease-associated regulation

Tissue flow regulates planar cell polarity independently of the Frizzled core pathway

Plasma membrane phosphatidylinositol (4,5)-bisphosphate is critical for determination of epithelial characteristics.

PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity

PI4P/PS countertransport by ORP10 at ER–endosome membrane contact sites regulates endosome fission

Establishment of mouse line showing inducible priapism-like phenotypes.

Altering phosphoinositides in high-fat diet-associated prostate tumor xenograft growth.

Dynamic erectile responses of a novel penile organ model utilizing TPEM†.

Endogenous YAP1 activation drives immediate onset of cervical carcinoma in situ in mice.

Collaborators (16)

Haruhiko Miyata

Tadahiro Kitamura

Tomohiko Taguchi

Joshua Pemberton

Tsutomu Sasaki

Gen Yamada

Koh Takeuchi

Akiko Sakai

Tomohiko Maehama

Makoto Shimozawa

Atsuo Sasaki

Olli Pietilainen

Christoph Thiele

Toyoshi Fujimoto

Elina Ikonen

Miesje van der Stoel

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