Atsuo Sasaki

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Project Professor

Hiroshima University Hospital

Japan

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About

Dr. Atsuo Sasaki is a Project Professor at Hiroshima University Hospital in Japan. His research primarily focuses on the mechanisms of cellular regulation and the therapeutic potential of various inhibitors. Recent publications include studies on PI5P4K inhibitors, tRNA regulation in response to DNA damage, and the molecular evolution of GTP sensing kinases. Dr. Sasaki's work contributes significantly to understanding cancer biology and metabolic diseases.

Recent Grants

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Therapeutic resistance and aggressive malignancy in glioblastomas: the contribution of GTP metabolism through regulation by IMPDH2

Open Date: 2021-07-01

Close Date: 2026-06-01

Grant: Close

Synthetic Lethal Combination of KRP203/Fingolimod with PI3K signaling for glioblastoma multiforme death by catastrophic vacuolization

Open Date: 2016-09-01

Close Date: 2018-08-31

Grant: Close

Targeting the Novel PI5P4K Pathway to Induce Glioblastoma Senescence

Open Date: 2014-09-30

Close Date: 2019-08-31

Grant: Close

Chemical Probes That Modulate Phosphatidylinositol-5-Phosphate 4-Kinase Activity

Open Date: 2012-01-01

Close Date: 2013-12-31

Articles (18)

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2020

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2020

Collaborators (14)

Tadahiro Kitamura

JAPAN

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sharon campbell

Liebscher Distinguished Professor

University of North Carolina at Chapel Hill

UNITED STATES

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University of North Carolina

UNITED STATES

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Susumu Goyama

JAPAN

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Takehiko Sasaki

Professor

Tokyo Medical and Dental University

JAPAN

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Takeharu Sakamoto

Kansai Medical University

JAPAN

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So Nakagawa

Associate Professor

Tokai University School of Medicine

JAPAN

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Atsuo Sasaki

Research Interests

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About

Recent Grants

Articles (18)

PI5P4K inhibitors: promising opportunities and challenges

MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes

SLFN11-mediated tRNA regulation induces cell death by disrupting proteostasis in response to DNA-damaging agents

A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion

Functional molecular evolution of a GTP sensing kinase: PI5P4Kβ

Epigenetic upregulation of Schlafen11 renders WNT-and SHH-Activated medulloblastomas sensitive to cisplatin

Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&amp;ATP assay

Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells

IMPDH inhibition activates TLR‐VCAM1 pathway and suppresses the development of MLL‐fusion leukemia

Beyond Warburg: LDHA activates RAC for tumour growth

Divergent Mechanisms Activating RAS and Small GTPases Through Post-translational Modification

Mycophenolate Mofetil Hepatotoxicity Associated with Mitochondrial Abnormality in Liver Transplant Recipients and Mice

Reuse of Molecules for Glioblastoma Therapy

SI-MOIRAI: A new method to identify and quantify the metabolic fate of nucleotides

Schlafen 11 predicts response to platinum-based chemotherapy in gastric cancers

TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers

GTP metabolic reprogramming by IMPDH2: unlocking cancer cells' fuelling mechanism

Metabolic Compartmentalization at the Leading Edge of Metastatic Cancer Cells

Collaborators (14)

Tadahiro Kitamura

sharon campbell

Kaori Fukuzawa

Xiaoyang Qi

Hitoshi Takizawa

Tsutomu Sasaki

Koh Takeuchi

Junko Murai

Hiromichi Ebi

Venkat R Chirasani

Susumu Goyama

Takehiko Sasaki

Takeharu Sakamoto

So Nakagawa

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Homogeneous luminescent quantitation of cellular guanosine and adenosine triphosphates (GTP and ATP) using QT-LucGTP&ATP assay