theodore holman

Professor

University of California, Santa Cruz

United States

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Professor Theodore Holman is a faculty member at the University of California Santa Cruz, USA. His research focuses on the biochemical processes involving lipoxygenases, particularly in relation to fatty acids and their implications for human health. Recent publications highlight his work on the structural and functional investigations of human lipoxygenases and their roles in biosynthetic pathways related to inflammation and resolution.

Articles (10)

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2023

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2023

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2023

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2023

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2022

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2022

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2021

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2020

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2020

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2020

Collaborators (6)

Alisa Glukhova

MONASH UNIVERSITY

AUSTRALIA

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Matthew Jacobson

Professor

UCSF

UNITED STATES

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Michael Holinstat

University of Michigan

UNITED STATES

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David M. Thal

AUSTRALIA

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Adam Offenbacher

East Carolina University

UNITED STATES

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Steven Perry

Assistant Professor

University Of Montana Western

UNITED STATES

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theodore holman

Research Interests

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Articles (10)

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes

Investigating the catalytic efficiency of C22-Fatty acids with LOX human isozymes and the platelet response of the C22-oxylipin products

Biochemical and hydrogen-deuterium exchange studies of the single nucleotide polymorphism Y649C in human platelet 12-lipoxygenase linked to a bleeding disorder

Structural basis for altered positional specificity of 15-lipoxygenase-1 with 5S-HETE and 7S-HDHA and the implications for the biosynthesis of resolvin E4.

Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity

In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2

Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1.

Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators.

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5

Collaborators (6)

Alisa Glukhova

Matthew Jacobson

Michael Holinstat

David M. Thal

Adam Offenbacher

Steven Perry

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