Michael Holinstat

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University of Michigan

United States

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Recent Grants

Grant: Close

Role of 12-lipoxygenase in platelet reactivity and type 2 diabetes mellitus

Open Date: 2013-08-01

Close Date: 2018-05-31

Grant: Close

12-HETrE regulation of platelets

Open Date: 2013-08-01

Close Date: 2018-07-31

Grant: Close

Genetic regulation of racial differences in platelet reactivity

Open Date: 2013-07-09

Close Date: 2018-02-28

Grant: Close

Thrombin regulation of Rap1 signaling in human platelet activity

Open Date: 2007-08-01

Close Date: 2008-09-23

Grant: Close

Thrombin regulation of Rap1 signaling in human platelet activity

Open Date: 2007-08-01

Close Date: 2012-04-30

Articles (19)

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2023

Collaborators (11)

Alisa Glukhova

MONASH UNIVERSITY

AUSTRALIA

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theodore holman

Professor

University of California, Santa Cruz

UNITED STATES

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Stephanie Smith

Research Assistant Professor

University of Michigan

UNITED STATES

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Andrea Obi

University of Michigan Hospital

UNITED STATES

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David M. Thal

AUSTRALIA

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Peisong Ma

Associate Professor

Thomas Jefferson University

UNITED STATES

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Kathryn Uhrich

Distinguished Professor

University of California, Riverside

UNITED STATES

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James Morrissey

University of Michigan

UNITED STATES

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Steven McKenzie

Professor

Thomas Jefferson University

UNITED STATES

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James V. Michael

Thomas Jefferson University

UNITED STATES

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Suzana Straus

Professor

The University of British Columbia

CANADA

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Michael Holinstat

Research Interests

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Recent Grants

Articles (19)

Clot Accumulation in 3D Microfluidic Bifurcating Microvasculature Network

An age-progressive platelet differentiation path from hematopoietic stem cells causes exacerbated thrombosis

Abstract 148: Loss Of Tlr4 Signaling Inhibits Thrombus Resolution In A Non-monocyte Dependent Manner

Composition of thrombi in zebrafish: similarities and distinctions with mammals

418 The antiplatelet effects of EPA, an omega-3 fatty acid, are mediated by its 12-lipoxygenase metabolite, 12-HEPE

SOTAGLIFLOZIN, A FIRST-IN-CLASS SGLT1/2 INHIBITOR, INHIBITS CLOTTING POTENTIAL IN THE VESSEL VIA INHIBITION OF PLATELET ACTIVATION, INTEGRIN ACTIVATION, AND AGGREGATION IN HUMAN PLATELETS

Smart thrombosis inhibitors without bleeding side effects via charge tunable ligand design.

Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets

The oxylipin analogue CS585 prevents platelet activation and thrombosis through activation of the prostacyclin receptor.

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes

Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition

Bioactive lipid regulation of platelet function, hemostasis, and thrombosis

Ribosomal protein control of hematopoietic stem cell transformation through direct, non-canonical regulation of metabolism.

Cargo-free particles divert neutrophil-platelet aggregates to reduce thromboinflammation

423 An omega-6-derived eicosanoid negatively regulates platelet reactivity of cardiovascular patients at increased risk for thrombosis

Antiplatelet strategies: past, present, and future

HDAC inhibitor CS014 inhibits platelet activity, small and large vessel thrombosis while maintaining haemostasis in a dose-dependent manner

Superiority of CS585 as a selective prostacyclin receptor agonist in prevention of thrombosis

Collaborators (11)

Alisa Glukhova

theodore holman

Stephanie Smith

Andrea Obi

David M. Thal

Peisong Ma

Kathryn Uhrich

James Morrissey

Steven McKenzie

James V. Michael

Suzana Straus

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