David M. Thal

Australia

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Articles (14)

Year:

2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

Collaborators (14)

Alisa Glukhova

MONASH UNIVERSITY

AUSTRALIA

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Emma van der Westhuizen

MONASH UNIVERSITY

AUSTRALIA

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theodore holman

Professor

University of California, Santa Cruz

UNITED STATES

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Manuela Joerg

Senior Lecturer

Monash University Malaysia.

AUSTRALIA

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Michael Holinstat

University of Michigan

UNITED STATES

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Yifan Cheng

University of California, San Francisco

UNITED STATES

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Ron O. Dror

Stanford University

UNITED STATES

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Sebastian Furness

MONASH UNIVERSITY

AUSTRALIA

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Kaleeckal Harikumar

Assistant professor in Medicine, Senior Research Scientist,

Mayo Clinic

UNITED STATES

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Arthur Christopoulos

MONASH UNIVERSITY

AUSTRALIA

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Celine Valant

MONASH UNIVERSITY

AUSTRALIA

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Patrick M. Sexton

MONASH UNIVERSITY

AUSTRALIA

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Matthew J. Belousoff

MONASH UNIVERSITY

AUSTRALIA

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Peter J. Scammells

MONASH UNIVERSITY

AUSTRALIA

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David M. Thal

Research Interests

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Articles (14)

Positive allosteric modulation of a GPCR ternary complex

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders

Structural basis of efficacy-driven ligand selectivity at GPCRs

Author Correction: Structural basis of efficacy-driven ligand selectivity at GPCRs

Cryo-EM structures of human arachidonate 12S-Lipoxygenase (12-LOX) bound to endogenous and exogenous inhibitors

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR

Recessive <scp><i>CHRM5</i></scp> variant as a potential cause of neurogenic bladder

The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor

Biased Profile of Xanomeline at the Recombinant Human M<sub>4</sub> Muscarinic Acetylcholine Receptor

The P2X1 receptor as a therapeutic target

Selective G protein signaling driven by substance P–neurokinin receptor dynamics

Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity

Collaborators (14)

Alisa Glukhova

Emma van der Westhuizen

theodore holman

Manuela Joerg

Michael Holinstat

Yifan Cheng

Ron O. Dror

Sebastian Furness

Kaleeckal Harikumar

Arthur Christopoulos

Celine Valant

Patrick M. Sexton

Matthew J. Belousoff

Peter J. Scammells

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