Thomas Prisinzano

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Professor

University of Kentucky

United States

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About

Thomas Prisinzano is a Professor at the University of Kentucky, United States. His research primarily focuses on opioid receptor probes, pharmacokinetics of pharmaceutical compounds, and the functional activity of various analogues related to pain and side effects. He has contributed to significant discoveries in the fields of analgesics and neuropharmacology, as evidenced by his recent publications.

Recent Grants

Grant: Close

Development of Agents for Synthetic Opioid Overdose

Open Date: 2021-09-01

Close Date: 2024-07-31

Grant: Close

Investigation of Neoclerodanes as Novel Opioid Ligands

Open Date: 2004-07-01

Close Date: 2021-02-28

Articles (20)

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2025

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (7)

Samuel Williamson

UNITED STATES

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Binghe Wang

Associate Professor

North Carolina State University

UNITED STATES

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Bronwyn Kivell

Associate Professor

Victoria University of Wellington

NEW ZEALAND

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Dan Luo

University of Kentucky

UNITED STATES

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Hideaki Kakeya

Professor

Kyoto University

JAPAN

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Kelly Frances Paton

University of Melbourne

AUSTRALIA

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A. Douglas Kinghorn

Professor and Jack L. Beal Chair

Ohio State University

UNITED STATES

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Thomas Prisinzano

Research Interests

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About

Recent Grants

Articles (20)

Winners of the 2024 Tu Youyou Award

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol

Effects of Biased Analogues of the Kappa Opioid Receptor Agonist, U50,488, in Preclinical Models of Pain and Side Effects

N-(3-Hydroxyphenyl)-3,8-diazabicyclooctanes as opioid receptors probes. 1. Investigation of the phenolic hydroxyl group

Stuffed Epimerase Domains of Pyochelin Biosynthesis are Defunct Methyltransferases

Preclinical Pharmacokinetic Evaluation of Mithramycin and Mithramycin SA Tryptophan-Conjugated Analog

Transformation of a Potent C9-Substituted Phenylmorphan into MOR Partial Agonists with Improvement of Metabolic Stability: An In Vitro, In Vivo, and In Silico Study

Functional Activity of Enantiomeric Oximes and Diastereomeric Amines and Cyano Substituents at C9 in 3-Hydroxy-N-phenethyl-5-phenylmorphans

Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone + rapamycin‐induced demyelination in mice

A MOR Antagonist with High Potency and Antagonist Efficacy among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-hydroxy)phenylmorphans

The Kappa Opioid Receptor Agonist 16-Bromo Salvinorin A Has Anti-Cocaine Effects without Significant Effects on Locomotion, Food Reward, Learning and Memory, or Anxiety and Depressive-like Behaviors

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

Potent MOR Agonists from 2′-Hydroxy-5,9-dimethyl-N-phenethyl Substituted-6,7-benzomorphans and from C8-Hydroxy, Methylene and Methyl Derivatives of N-Phenethylnormetazocine

Synthesis and Pharmacological Evaluation of Enantiopure N-Substituted Ortho-c Oxide-Bridged 5-Phenylmorphans

A Journey through Diastereomeric Space: The Design, Synthesis, In Vitro and In Vivo Pharmacological Activity, and Molecular Modeling of Novel Potent Diastereomeric MOR Agonists and Antagonists

Structure-activity studies of PTPRD phosphatase inhibitors identify a 7-cyclopentymethoxy illudalic acid analog candidate for development

Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent.

The kappa-opioid receptor agonist, triazole 1.1, reduces oxycodone self-administration and enhances oxycodone-induced thermal antinociception in male rats.

Profile of a short-acting κ-antagonist, LY2795050, on self-grooming behaviors, forced swim test and locomotor activity: sex comparison in mice

Discriminative-stimulus effects of synthetic cathinones in squirrel monkeys.

Collaborators (7)

Samuel Williamson

Binghe Wang

Bronwyn Kivell

Dan Luo

Hideaki Kakeya

Kelly Frances Paton

A. Douglas Kinghorn

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