Tim Thomas

Associate Professor

Walter and Eliza Hall Institute of Medical Research

Australia

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Articles (14)

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2021

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2021

Collaborators (7)

Belinda Phipson

Lab head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Dianbo Qu

CANADA

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Vincent Harley

MONASH UNIVERSITY

AUSTRALIA

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Gordon Smyth

Honorary Professorial Fellow

University of Melbourne

AUSTRALIA

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Paul Stupple

Monash University Malaysia.

AUSTRALIA

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Susan Charman

MONASH UNIVERSITY

AUSTRALIA

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Daniel Gray

Joint Division Head and Laboratory Head

Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Tim Thomas

Research Interests

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Articles (14)

ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.

PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS

Increasing histone acetylation improves sociability and restores learning and memory in KAT6Bhaploinsufficient mice

The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function

FGF9 variant in 46,XY DSD patient suggests a role for dimerization in sex determination

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.

Reference compounds for characterizing cellular injury in high-content cellular morphology assays

Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7

The chromatin reader protein ING5 is required for normal hematopoietic cell numbers in the fetal liver

Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest.

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death.

The acetyltransferase KAT7 is required for thymic epithelial cell expansion, expression of AIRE target genes, and thymic tolerance

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal.

The histone acetyltransferase HBO1 promotes efficient tip cell sprouting during angiogenesis.

Collaborators (7)

Belinda Phipson

Dianbo Qu

Vincent Harley

Gordon Smyth

Paul Stupple

Susan Charman

Daniel Gray

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