Gordon Smyth

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Honorary Professorial Fellow

University of Melbourne

Australia

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About

Gordon Smyth is an Honorary Professorial Fellow at the University of Melbourne, Australia. His research spans various areas including immunogenetics, differential expression analysis, and spatial transcriptomics. Recent articles co-authored by Professor Smyth contribute to understanding cardiomyopathies, histone modifications, and the functionality of immune cells. He is recognized for his advancements in statistical methodologies for analyzing sequencing data.

Recent Grants

Grant: Close

Adapting limma and edgeR for Single-cell and Proteomics

Open Date: 2021-09-01

Close Date: 2023-09-01

Grant: Close

Enabling Differential Analyses of Genomic Data with limma, edgeR and Glimma

Open Date: 2019-12-01

Close Date: 2020-12-01

Grant: Close

Statistical bioinformatics for genomic research

Open Date: 2019-01-01

Close Date: 2023-12-01

Articles (10)

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2025

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2025

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2024

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2024

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2024

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2024

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Walter and Eliza Hall Institute of Medical Research

AUSTRALIA

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Gordon Smyth

Research Interests

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Contact this professor

About

Recent Grants

Articles (10)

T2T-CHM13 versus hg38: accurate identification of immunoglobulin isotypes from scRNA-seq requires a genome reference matched for ancestry

KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan

Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data

edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets

ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development.

Increasing histone acetylation improves sociability and restores learning and memory in KAT6Bhaploinsufficient mice

Dividing out quantification uncertainty allows efficient assessment of differential transcript expression with edgeR.

Unraveling the diversity and functions of tissue-resident plasma cells

Proteomic and metabolomic analyses of the human adult myocardium reveal ventricle-specific regulation in end-stage cardiomyopathies

Faster and more accurate assessment of differential transcript expression with Gibbs sampling and edgeR v4

Collaborators (6)

Ilariya Tarasova

Matthew Ritchie

John O'Sullivan

Wei Shi

Joanna Groom

Tim Thomas

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