Timothy Tree

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Professor in Immune Regulation and Immunotherapy

King’s College London

United Kingdom

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About

Professor Timothy Tree is a faculty member at King's College London, specializing in Immune Regulation and Immunotherapy. His research focuses on autoimmune diseases, particularly type 1 diabetes, and the role of regulatory T cells in disease progression and therapy. Recent publications include studies on multi-omics analysis in diabetes and the immune response in gestational diabetes. He is recognized for his contributions to understanding immunological mechanisms in various clinical contexts.

Recent Grants

Grant: Close

Regulatory T cells can be divided into phenotypically distinct subsets which have differential in vitro suppressive capacity

Open Date: 2018-09-30

Close Date: 2022-06-29

Grant: Close

Harmonizing biomarkers in clinical trials of ustekinumab

Open Date: 2018-07-01

Close Date: 2024-06-30

Grant: Close

Immune studies in LEAP Trio

Open Date: 2018-01-01

Close Date: 2019-01-01

Grant: Close

USE OF LOW-DOSE IL-2 TO EXPAND ENDOGENOUS REGULATORY T CELLS AND ACHIEVE TRANSPLANTATION TOLERANCE

Open Date: 2017-07-17

Close Date: 2021-06-16

Grant: Close

The role of CD8:B lymphocyte interactions in Type 1 Diabetes pathogenesis

Open Date: 2016-09-25

Close Date: 2021-01-31

Articles (16)

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2024

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2022

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2022

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2022

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2022

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2021

Collaborators (23)

Rui Galao

King’s College London

UNITED KINGDOM

Timothy Tree

Research Interests

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About

Recent Grants

Articles (16)

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

Multi‐omics analysis reveals drivers of loss of <i>β</i>‐cell function after newly diagnosed autoimmune type 1 diabetes: An INNODIA multicenter study

A set of circulating microRNAs belonging to the 14q32 chromosome locus identifies two subgroups of individuals with recent-onset type 1 diabetes

Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans

Gene expression signature predicts rate of type 1 diabetes progression

Monitoring islet specific immune responses in type 1 diabetes clinical immunotherapy trials

Senescent-like Blood Lymphocytes and Disease Progression in Amyotrophic Lateral Sclerosis

Regulatory T cells in the peripheral blood of women with gestational diabetes

Highly sensitised individuals present a distinct Treg signature compared to unsensitised individuals on haemodialysis

Single-cell RNAseq identifies clonally expanded antigen-specific T-cells following intradermal injection of gold nanoparticles loaded with diabetes autoantigen in humans.

Concordance of B- and T-cell responses to SARS-CoV-2 infection, irrespective of symptoms suggestive of COVID-19.

INNODIA Master Protocol for the evaluation of investigational medicinal products in children, adolescents and adults with newly diagnosed type 1 diabetes

Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes

Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes

Humoral and cellular immunogenicity to a second dose of COVID-19 vaccine BNT162b2 in people receiving methotrexate or targeted immunosuppression: a longitudinal cohort study

A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes.

Collaborators (23)

Rui Galao

Yuk-Fun Liu

Ashish Marwaha

Tomi Suomi

James Russ-Silsby

Abdel Douiri

Todd Brusko

Anthony Dorling

Laura Cook

Panicos Shangaris

Rusung Tan

Megan Levings

Arnaud Zaldumbide

Emma Duncan

Knut Dahl-Jorgensen

Peng Zhang

Dirk Homann

Mark Peakman

Ezio Bonifacio

M. Loredana Marcovecchio

Tatjana Nikolic

Michael Malim

Alberto Sanchez-Fueyo

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