Jaime A. S. Coelho

We report a drug delivery system containing a cytotoxic ruthenium complex tethered to a FGFR-targeting peptide. The system showed controlled release of the active complex in breast cancer cells resulting in improved antiproliferative activity and selectivity.

Total synthesis of natural products is an important discipline of organic chemistry that has enabled the development of new synthetic methods and strategies for the preparation and study of the structure and reactivity of complex naturally occurring products. In this review we summarize the synthetic strategies developed in Portugal by several research groups for the synthesis of bioactive natural products including alkaloids, cyclitols, fatty alcohols, phenylpropanoic acids, γ‐butyrolactones, xanthones and nucleosides.