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Wytske M. van Weerden

Associate professor

Erasmus University Medical Center

Netherlands

Research Interests

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Professors in Netherlands Professors in Cell Biology Cell Biology professors in Netherlands

About

Wytske M. van Weerden is an Assistant Professor at Erasmus University Medical Center in the Netherlands. Her research primarily focuses on prostate cancer, including studies on drug resistance, patient-derived models, and the mechanisms of tumor growth and treatment efficacy. Recent articles by Dr. van Weerden explore the dynamics of androgen receptor mutations, as well as innovative strategies to enhance anti-tumor activity in prostate cancer therapies.

Articles (26)

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Collaborators (19)

Elena Martens-Uzunova

Assistant professor

Erasmus University Rotterdam

NETHERLANDS

Wytske M. van Weerden

Research Interests

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Articles (26)

Patient-derived models of prostate cancer

Comparative analysis of second and third-generation nanobody-based CAR-NK cells targeting PSMA in prostate cancer immunotherapy

TMPRSS2-ERG confers resistance of prostate cancer to antiandrogens

Using advanced cell models for targeted radionuclide therapy evaluation

Cell-Based Immunization Combined with Single-Round Cell Panning Enables Discovery of PSMA-Targeting Nanobodies from Phage Display Libraries

Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice

Nanobody-Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Darolutamide does not interfere with OATP‐mediated uptake of docetaxel

Defining the challenges and opportunities for using patient‐derived models in prostate cancer research

Pre-existing cell subpopulations in primary prostate cancer tumors display surface fingerprints of docetaxel-resistant cells

Capivasertib combines with docetaxel to enhance anti-tumour activity through inhibition of AKT-mediated survival mechanisms in prostate cancer

Darolutamide added to docetaxel augments antitumor effect in models of prostate cancer through cell cycle arrest at the G1-S transition

Prostate cancer androgen biosynthesis relies solely on CYP17A1 downstream metabolites

The future of patient-derived xenografts in prostate cancer research

Viability Analysis and High-Content Live-Cell Imaging for Drug Testing in Prostate Cancer Xenograft-Derived Organoids

Androgen receptor mutations modulate activation by 11-oxygenated androgens and glucocorticoids

Awe and anxiety for cancer cells: connecting scientists and patients in a holistic approach of metastasis research

GRPR versus PSMA

Patient-Derived Xenografts and Organoids Recapitulate Castration-Resistant Prostate Cancer with Sustained Androgen Receptor Signaling

Preclinical Assessment of the Combination of PSMA-Targeting Radionuclide Therapy with PARP Inhibitors for Prostate Cancer Treatment

Abiraterone switches castration‐resistant prostate cancer dependency from adrenal androgens towards androgen receptor variants and glucocorticoid receptor signalling

Radiolabeled Bombesin Analogs

Modeling Prostate Cancer Treatment Responses in the Organoid Era: 3D Environment Impacts Drug Testing

Patient-Derived Xenograft Models in Cancer Research

The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel‐resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe

NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice—A Novel in Vivo Imaging Platform

Collaborators (19)

Elena Martens-Uzunova

Stefan Buck

Jack A. Schalken

Shuiying Hu

Guido Jenster

Simone Dalm

Pim French

David Goode

Dik C. van Gent

W. Nathaniel Brennen

Pieter Vader

Renea Taylor

Martin van Royen

Natalie Lister

Hub Zwart

Vladimir Student

Harmen van de Werken

Jan Bouchal

Sofia Karkampouna

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