Harmen van de Werken

Assistant Professor Computational Biology & Bioinformatics at the Department of Immunology

Erasmus MC

Netherlands

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Harmen van de Werken is an Assistant Professor in Computational Biology & Bioinformatics at the Department of Immunology, Erasmus MC, Netherlands. His research areas encompass immunology, bioinformatics, and computational biology, with recent articles focusing on topics such as tumor regression related to peptide translation, the effects of metabolic dysfunction in chronic hepatitis B, and the application of machine learning in predicting COVID-19 severity. He is dedicated to advancing the understanding of complex biological processes through innovative research methodologies.

Harmen van de Werken

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Articles (23)

CTG-initiated cryptic peptide translation up and downstream of a canonical ATG start codon is enhanced by TLR stimulation and induces tumor regression in mice

Metabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in patients with chronic hepatitis B

Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11

Association of HBsAg levels with differential gene expression in NK, CD8 T, and memory B cells in treated patients with chronic HBV

B cell activation gene signature in blood and liver of HBeAg+ immune active chronic hepatitis B patients

Intrahepatic plasma cells, but not atypical memory B cells, associate with clinical phases of chronic hepatitis B

Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

An explainable machine learning model for COVID-19 severity prognosis at hospital admission

Tumor organoids improve mutation detection of pancreatic ductal adenocarcinoma

The Impact of Spliceosome Inhibition in <i>SF3B1</i>-Mutated Uveal Melanoma

Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK

Personalised decision making to predict absolute metastatic risk in cutaneous squamous cell carcinoma: development and validation of a clinico-pathological model

The genomic and transcriptomic landscape of advanced renal cell cancer for individualized treatment strategies

Single-cell RNA sequencing of liver fine-needle aspirates captures immune diversity in the blood and liver in chronic hepatitis B patients

Evaluation of pre-processing methods for tear fluid proteomics using proximity extension assays

Identifying somatic changes in drug transporters using whole genome and transcriptome sequencing data of advanced tumors

Overcoming immune checkpoint blockade resistance in solid tumors with intermittent ITK inhibition.

TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model

Patient-Derived Xenografts and Organoids Recapitulate Castration-Resistant Prostate Cancer with Sustained Androgen Receptor Signaling

Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors

Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors

Trained Immunity in Primary Sjögren’s Syndrome: Linking Type I Interferons to a Pro-Atherogenic Phenotype

Collaborators (14)

Peter Katsikis

Andre Boonstra

Guido Jenster

Marlies Wakkee

Martin van Royen

Marlies Gijs

Adam J. Gehring

Ron Mathijssen

Wytske M. van Weerden

Alastair Kilpatrick

Erwin Brosens

Christos Ouzounis

Selin Tokez

Casper Rokx

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