Your Twin learns with you

30% off annual Pro20% off monthly Pro

Ends in00h00m00s

Publisher
source

The University of Manchester

Top university

Just Landed

FSE PhD President's Doctoral Scholarship: Phase-optimised PUFA Production in Oleaginous Yeast via Transcriptomics-Guided Enzyme-Constrained Metabolic Modelling The University of Manchester in United Kingdom

Degree Level

PhD

Field of study

Computer Science

Funding

Available

Deadline

Dec 18, 2026

Country flag

Country

United Kingdom

University

The University of Manchester

Apply for this scholarship

Keywords

Computer Science
Biomedical Engineering
Chemical Engineering
Biology
Systems Biology
Metabolic Engineering
Rna-seq
Statistics
Transcriptomic

Suggested scholarships

Publisher
source

University of Birmingham

Country flag

United Kingdom

This PhD studentship at the University of Birmingham develops a mechanistic mathematical framework to explain how biofilm-associated infections lead to host-cell damage. The project focuses on the coupled biology of biofilm growth, nutrient transport, bacterial toxins, reactive oxygen species, inflammatory signalling, DNA damage, repair failure, and host-cell viability. The student will build and analyse models that connect biofilm structure with local biochemical gradients and tissue injury acr...

Inflammation
Computer Science
Biomedical Engineering
+9 more

Posted Yesterday

Publisher
source

University of Exeter

Country flag

United Kingdom

[Home tuition fees plus a Doctoral Stipend for up to 4 years.] PhD Studentship at the University of Exeter in From Variants to Placental Function: Using Cell-free DNA to Dissect the Functional Genomics of Adverse Pregnancy Outcomes . This project explores how genetic variants influence placental biology and adverse pregnancy outcomes such as preeclampsia, foetal growth restriction, and pre-term delivery. The research uses cell-free DNA (cfDNA) from maternal blood as a minimally invasive way to i...

Computer Science
Biomedical Engineering
Biology
+5 more

1 week ago

Publisher
source

University of Exeter

Country flag

United Kingdom

[Home tuition fees plus a Doctoral Stipend for up to 4 years.] PhD Studentship at the University of Exeter on rare variant functional genomics for better understanding, prevention and treatment of musculoskeletal disorders. This interdisciplinary studentship focuses on uncovering the genetic architecture and biological mechanisms underlying disabling musculoskeletal conditions such as osteoarthritis and Dupuytren’s contracture. The project combines large-scale human genomics, statistical analysi...

Computer Science
Biology
Functional Genomics
+5 more

1 week ago

Publisher
source

University of Exeter

Country flag

United Kingdom

[Funding of fees plus a stipend of £21,805 per annum for 2026/7.] This is a fully funded PhD studentship at the University of Exeter focused on decoding cellular diversity in the human brain and functionally annotating neuronal subtypes across development and disease. The project addresses a major challenge in neuroscience: while single-cell RNA sequencing has revealed many excitatory and inhibitory neuronal subtypes, the regulatory mechanisms that establish and maintain these identities are sti...

Computer Science
Biomedical Engineering
Biology
+10 more

1 week ago

Publisher
source

University College London

Country flag

United Kingdom

The London Interdisciplinary Biosciences Consortium (LIDo) is advertising fully funded PhD studentships for September 2027 entry. The programme is a collaborative doctoral training partnership focused on bioscience and biotechnology , with strong interdisciplinary training across biological sciences , computer science , AI , machine learning , data science , mathematical modelling , and related physical, chemical, engineering, and computational methods. Students will train within a consortium of...

Computer Science
Data Science
Biomedical Engineering
+11 more

1 month ago

About this position

[Annual stipend at the UKRI minimum rate of £21,805 per year plus a £1,000 per annum enhancement, and a research training support grant of up to £20,000 for the full 4-year programme.]

This PhD studentship at The University of Manchester focuses on improving the production of polyunsaturated fatty acids (PUFAs) in oleaginous yeasts using a transcriptomics-guided, enzyme-constrained metabolic modelling approach.

The project aims to connect RNA-seq data, proteomics, genome-scale metabolic models, and fermentation data to predict and improve production efficiency across selected yeast hosts. The student will work on a design-build-test-learn cycle that includes curating native phase-responsive promoters, characterising promoter kinetics with RNA light-up aptamers, constructing phase-specific expression cassettes, and testing engineered strains in controlled fermentations under exponential and nitrogen-limited conditions.

Research activities will also include lipid analysis by GC-MS, phase-resolved RNA-seq, LC-MS proteomics, and the use of genome sequence and annotation data to support model construction and strain selection. On the modelling side, the project will apply enzyme-constrained flux scanning based on enforced objective flux and kinetic flux control coefficient analysis to identify pathway demands, bottlenecks, and overexpression opportunities.

The work is framed around selected oleaginous yeasts such as Yarrowia lipolytica, Rhodotorula toruloides, and Lipomyces starkeyi, with modelling outputs guiding successive rounds of strain engineering. The project sits within a quantitative, systems-level biotechnology research environment and is intended to generate predictive models of PUFA production efficiency under different genetic and process scenarios.

The main project supervisor is Dr Martin.

Funding details

Available

What's required

Open to both Home (UK) and international applicants. Applicants must submit a formal application through the online portal, specifying the full project title and supervisor(s), details of previous study, and names and contact details of two referees. A Supporting Statement, CV, and transcripts of awarded and in-progress university qualifications must also be uploaded. Late or incomplete applications will not be considered.

How to apply

Contact the main project supervisor, Dr Martin, to discuss the project before applying. Submit a formal application through the University of Manchester online portal and select the FSE PhD President’s Doctoral Scholarship programme. Upload the required supporting statement, CV, transcripts, and referee details.

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts and confirm requirements with the provider.