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Larrosa
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PhD Studentship – FSE PhD President's Doctoral Scholarship Engineering: Chemical Probes to Sense Dynamic Molecular Neighbourhoods in Living Cells The University of Manchester in United Kingdom
Degree Level
PhD
Field of study
Cell Biology
Funding
Available
Deadline
Dec 18, 2026
Country
United Kingdom
University
The University of Manchester
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Keywords
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About this position
This PhD studentship at The University of Manchester develops new chemically engineered proximity probes for sensing dynamic molecular neighbourhoods in living cells. The project addresses a key challenge in proximity labelling: how to create a measurable signal without disturbing sensitive biological systems, while also controlling how far the labelling chemistry reaches.
The successful student will design and synthesise a library of new probe molecules and systematically vary their chemical and physical properties to tune probe behaviour. The work combines synthetic chemistry with biochemical and cellular experiments to understand how molecular structure controls labelling efficiency, biological compatibility and spatial precision.
Experimental studies will include biochemical assays, advanced fluorescence imaging and super-resolution microscopy in living cells. The project will then test selected probes in more challenging biological systems where conventional proximity labelling may itself perturb the processes under study. Proteomic analysis will be used selectively to identify molecular networks revealed by the new sensing platform.
The advert indicates that preliminary work from the supervisory team supports the feasibility of the idea, while leaving room for fundamental discovery and technology development. The project sits at the interface of chemical probe design, chemical biology and cellular analysis in a research environment focused on developing new tools for studying signalling inside cells.
Funding details
Available
What's required
Applicants are expected to hold, or be about to obtain, a minimum upper second-class undergraduate honours degree (or equivalent) in Chemistry, Pharmacy or related areas. Research experience is mentioned as desirable/expected in the advert. Applicants must submit a full application with details of previous study, two referees, a supporting statement, CV and transcripts, and late or incomplete applications will not be considered.
How to apply
Contact the main project supervisor, Prof Larrosa, to discuss suitability before applying. Submit a formal application through the online portal and select the FSE PhD President’s Doctoral Scholarship programme. Include the full project title and supervisor name(s), details of previous study, two referees, a supporting statement, CV, and transcripts.
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Professors
Professor at The University of Manchester
United Kingdom
Research Interests
Pharmacy
Cell Biology
Biology
Chemical Biology
Super-resolution Microscopy
Make your next move.
Prepare your application
Review drafts and confirm requirements with the provider.