University of Exeter
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PhD Studentship: Functional genomic approaches to convergent mechanisms in chromatinopathies University of Exeter in United Kingdom
Degree Level
PhD
Field of study
Psychology
Funding
Available
Deadline
Jan 5, 2027
Country
United Kingdom
University
University of Exeter
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About this position
PhD Studentship at the University of Exeter in functional genomic approaches to convergent mechanisms in chromatinopathies.
This project explores a major unmet medical need in rare genetic disease research: understanding whether several chromatinopathies share overlapping molecular mechanisms that could be targeted by the same drug treatment. Chromatinopathies are caused by variants in genes involved in chromatin remodelling and are often associated with developmental delay, intellectual disability, autism, and other neurodevelopmental features. The proposed research uses functional genomics to investigate transcriptomic and epigenomic changes in the brain and to test how treatment alters these disease-associated pathways.
The studentship is based at the University of Exeter and focuses on three prioritised chromatinopathies. The project asks how gene expression and chromatin state differ across cell types in the mouse frontal cortex, how these changes respond to treatment, and whether treatment can rescue behavioural phenotypes. The work combines single-nucleus RNA sequencing (snRNA-seq), bulk RNA-seq, and CUT&Tag-seq with mouse behavioural studies assessing anxiety, activity, repetitive behaviour, social behaviour, motor function, learning, and memory. In parallel, human neuron data from patient-derived and control iPSC models treated with the same drug will be analysed for cross-species comparison.
The student will work closely with an expert post-doctoral scientist and can build on sequencing datasets that have already been collected. The project is therefore well suited to a student interested in computational and experimental genomics, neurobiology, chromatin biology, and translational research on rare disease therapies.
Funding: The studentship provides Home tuition fees plus a Doctoral Stipend for up to 4 years.
Eligibility and focus: The advert does not list detailed formal entry requirements, but the project would suit applicants with strong interest in genomics, epigenomics, neuroscience, mouse work, and data analysis. The topic is highly relevant to students interested in rare disease biology, brain development, and drug-response mechanisms.
Deadline: 05 Jan (normalized date: 2027-01-05).
Funding details
Available
What's required
No formal entry requirements are specified in the advert. The project would suit a candidate with interest in functional genomics, neurodevelopmental disease biology, mouse models, sequencing data analysis, and behavioural phenotyping. Experience with next-generation sequencing, transcriptomics, epigenomics, or bioinformatics would be advantageous if available.
How to apply
Apply via the University of Exeter funding/application link provided in the advert. Prepare and submit your application before the deadline of 05 Jan. Review the project details carefully and ensure your materials address the genomics, mouse, and neuroscience aspects of the studentship.
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Make your next move.
Prepare your application
Review drafts and confirm requirements with the provider.