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The University of Manchester

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PhD Studentship: The Role of Adaptive Evolution in the Microbial Sensing of Anthropogenic Molecules The University of Manchester in United Kingdom

Degree Level

PhD

Field of study

Biochemistry

Funding

Available

Deadline

Dec 18, 2026

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Country

United Kingdom

University

The University of Manchester

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Keywords

Biochemistry
Molecular Biology
Chemistry
Microbiology
Environmental Science
Biology
Gene Expression
Bacterial Genetics
Transcriptomic

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About this position

[4-year PhD studentship with annual stipend at the UKRI minimum rate (currently £21,805 per year) plus £1,000 per year enhancement, and a research training support grant of up to £20,000 for the full 4-year programme.]

This PhD studentship at The University of Manchester investigates how microbes sense and respond to anthropogenic molecules released from discarded plastics. The project is framed around a major environmental and biological question: whether microbial communities can detect small-molecule breakdown products from plastics and adapt their behaviour or evolve mechanisms that enable such sensing.

The successful student will work on the biochemical and genetic responses of microbes exposed to plastic degradants. The project combines microbial culture experiments with growth profiling, transcriptomic analysis to identify induced genes, and proteomic DNA-binding approaches to pinpoint the proteins interacting with regulatory regions of differentially expressed genes. A key aim is to identify the transcription factors involved in molecular sensing and then validate their function in a model microorganism, E. coli.

The project is supervised by Dr Wong and is part of a funded doctoral scholarship competition. It offers training across microbiology, genetics, transcriptomics, proteomics, and molecular mechanisms of gene regulation in a research environment focused on microbial adaptation to environmental chemical exposure.

Funding details

Available

What's required

Applicants should hold, or expect to obtain, at least an upper second-class undergraduate honours degree (2:1), or an equivalent qualification, in microbiology, genetics, molecular biology, or another relevant subject. Research experience in bacterial microbiology or bacterial genetics is desirable.

How to apply

Contact Dr Wong to discuss the project before applying. Submit a formal application through the online application portal for the FSE PhD President’s Doctoral Scholarship programme. Include the project title, supervisor details, previous study information, two referees, a supporting statement, CV, and transcripts.

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