PhD Studentship: Uncovering the mechanism of minor spliceosome autoimmune diabetes University of Exeter in United Kingdom

[Funding of fees plus a stipend of £21,805 per annum for 2026/7. Funded by the EPSRC Engineering and Physical Sciences Research Council.] PhD Studentship at the University of Exeter: Allele-resolved genetics and epigenetics in type 2 diabetes This funded PhD studentship explores how genetic variation alters gene regulation in type 2 diabetes (T2D), with a focus on pancreatic islets. The project addresses a major challenge in human genetics: disease-associated DNA changes often act through regula...

[Full tuition fees plus a stipend of £21,805 per annum for 2026/7.] PhD studentship at the University of Exeter on developing a new variant effect predictor for multiple missense variants in the same protein molecule. This EPSRC-funded project tackles an important challenge in clinical genomics: most variant interpretation tools assess missense changes one at a time, even though many patients carry multiple variants in the same gene or protein. The project will develop and validate a new computa...

[Fees plus stipend of £21,805 per annum for 2026/7.] PhD studentship at the University of Exeter on next-generation machine learning for predicting genetic interactions in cancer, with a specific focus on pancreatic cancer. The project sits at the interface of computational genomics, machine learning, and cancer biology, and is funded by the Medical Research Council (MRC). The research tackles a major challenge in oncology: identifying genetic interactions, including synthetic lethality, that on...

[Home tuition fees plus a Doctoral Stipend for up to 4 years.] PhD Studentship at the University of Exeter in From Variants to Placental Function: Using Cell-free DNA to Dissect the Functional Genomics of Adverse Pregnancy Outcomes . This project explores how genetic variants influence placental biology and adverse pregnancy outcomes such as preeclampsia, foetal growth restriction, and pre-term delivery. The research uses cell-free DNA (cfDNA) from maternal blood as a minimally invasive way to i...

[Home tuition fees plus a Doctoral Stipend for up to 4 years.] PhD Studentship at the University of Exeter on rare variant functional genomics for better understanding, prevention and treatment of musculoskeletal disorders. This interdisciplinary studentship focuses on uncovering the genetic architecture and biological mechanisms underlying disabling musculoskeletal conditions such as osteoarthritis and Dupuytren’s contracture. The project combines large-scale human genomics, statistical analysi...