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U.S. Environmental Protection Agency

EPA Internship: Mode-of-Action Inference from High-Throughput Transcriptomics and Phenotypic Profiling Data U.S. Environmental Protection Agency (EPA) in United States

Degree Level

Postdoc

Field of study

Computer Science

Funding

Stipend of $7,789.00 monthly; appointment initially for one year and may be renewed three to four additional years subject to EPA recommendation and funding availability.

Deadline

Dec 4, 2026

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Country

United States

University

U.S. Environmental Protection Agency

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Keywords

Computer Science
Chemistry
Biology
Toxicology
Statistical Analysis
Computational Biology
High-throughput Screening
Medical Science
Regulatory Science
Next-generation Sequencing
Statistics
Bioinformatic
Transcriptomic

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About this position

This research internship at the U.S. Environmental Protection Agency in Research Triangle Park, North Carolina focuses on mode-of-action inference from high-throughput transcriptomics and phenotypic profiling data. The project sits within EPA’s Office of Chemical Safety and Pollution Prevention and contributes to the agency’s effort to develop and evaluate new approach methodologies for chemical safety assessment.

The selected participant will join a transdisciplinary research team working on alternative testing strategies designed to generate toxicity information more rapidly and cost-effectively than traditional animal testing. The project centers on using modern biological and computational data to support hazard identification and regulatory decision-making, with opportunities to contribute to original research and publications.

Training may include computational pipelines, bioinformatic approaches, statistical analysis, and quality assurance/quality control for complex biological datasets, including next-generation sequencing-based data. The research environment also includes literature review and evidence synthesis, experimental work with nucleic acids and cell culture, and testing chemicals or chemical mixtures in cell-free, cell-based, and high-throughput systems. The intern may also contribute to weight-of-evidence evaluations, data visualization, and presentations at scientific meetings.

The opportunity offers exposure to internationally recognized leaders within and outside EPA and is designed to build skills applicable to life sciences research and regulatory science.

Funding details

Stipend of $7,789.00 monthly; appointment initially for one year and may be renewed three to four additional years subject to EPA recommendation and funding availability.

What's required

Applicants should be currently pursuing or have received a doctoral degree in biology, toxicology, biochemistry, molecular biology, genetics, bioinformatics, computational biology, or a related field. The degree must have been received within the past five years, or be currently pursuing; applicants currently pursuing a doctorate degree such as PhD or MD will also be considered. Preferred experience includes computational skills such as programming and R-based statistics, familiarity with literature search tools and strategies, coursework in biostatistics and/or bioinformatics, experience with sequencing data, strong written, oral, and electronic communication skills, lab experience with nucleic-acid work in a nuclease-free environment and aseptic cell culture techniques, and basic molecular biology methods such as gel electrophoresis, PCR, qRT-PCR, thermocyclers, and/or bioanalyzers. Citizenship is restricted to U.S. citizens and Lawful Permanent Residents; a successful background investigation is required.

How to apply

Scroll to the bottom of the opportunity page and click APPLY. Submit the application, transcripts, current resume/CV, and two educational or professional recommendations; the application is incomplete until at least one recommendation is submitted. Ensure all documents are in English or include an official English translation.

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