Up to 30% off — ends 7 Aug
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Up to 30% off — ends 7 Aug
ONLY00h00m00s
James Spencer
Top university
10 months ago
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Overcoming ß-lactamase-mediated antibiotic resistance University of Bristol in United Kingdom
Degree Level
PhD
Field of study
Molecular Biology
Funding
Full funding availableDeadline
Expired
Country
United Kingdom
University
University of Bristol
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*Overcoming ß-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment*
GW4 Biomed Doctoral Training Programme 4 year PhD project
Co-supervisors: James Spencer , Catherine Tooke , Adrian Mulholland
Antibiotic resistance threatens human health. ß-lactamases cause resistance to ß-lactams, the most widely used antibiotics. Class C ß-lactamases are not well understood, but variants are emerging that help bacteria evade even ‘last resort’ treatments. By combining computer simulation (molecular dynamics, reaction simulations) and experimental methods (enzyme assays, crystallography) you will study how, finding links between structure and activity. This will help to regain the upper hand in the ‘biochemical warfare’ between humans and bacteria. The focus will be on the use of multiscale (QM/MM and ML/MM) reaction simulations.
Related publication: A. H. Lima, M. W. van der Kamp, 2025. Insights into the Enhanced Ceftazidime Hydrolysis by Ent385 AmpC ß-Lactamase from Multiscale Simulations. ACS Catal., 15, 11739–11748, DOI: 10.1021/acscatal.5c02383.
More information on project and DTP:
https://lnkd.in/e7ZC3wFR
Applications close Oct 20th, but please contact me before applying to the DTP (by October 5th), with a draft for the text fields on the application form.
Funding details
Full funding including tuition fees and living expenses is available for this position. The scholarship covers all educational costs and provides a monthly stipend.
How to apply
Please submit your application including a cover letter, CV, academic transcripts, and contact information for two references. Applications should be sent via the online portal before the deadline.
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