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James Spencer

Top university

1 year ago

Overcoming ß-lactamase-mediated antibiotic resistance University of Bristol in United Kingdom

Degree Level

PhD

Field of study

Molecular Biology

Funding

This is a fully funded 4-year PhD position through the GW4 BioMed Doctoral Training Programme. Funding covers tuition fees and provides a stipend for living expenses. The position is not self-funded and includes support for research activities.

Deadline

Expired

Country flag

Country

United Kingdom

University

University of Bristol

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Keywords

Molecular Biology
Chemistry
Microbiology
Biomedical Engineering
Biology
Crystallography
Structural Biology
Molecular Dynamics
Computational Biology
Health Science
Antibiotic Resistance
Enzyme Engineering

About this position

Phd position available at University of Bristol for microbiology background students!!

A fully funded 4-year PhD position in my group is available through the GW4 BioMed DTP. Applicants are selected by the DTP, with a choice of multiple projects; selection is highly competitive.

Details:
*Overcoming ß-lactamase-mediated antibiotic resistance by combining biomolecular simulation and experiment*
GW4 Biomed Doctoral Training Programme 4 year PhD project
Co-supervisors: James Spencer , Catherine Tooke , Adrian Mulholland

Antibiotic resistance threatens human health. ß-lactamases cause resistance to ß-lactams, the most widely used antibiotics. Class C ß-lactamases are not well understood, but variants are emerging that help bacteria evade even ‘last resort’ treatments. By combining computer simulation (molecular dynamics, reaction simulations) and experimental methods (enzyme assays, crystallography) you will study how, finding links between structure and activity. This will help to regain the upper hand in the ‘biochemical warfare’ between humans and bacteria. The focus will be on the use of multiscale (QM/MM and ML/MM) reaction simulations.

Related publication: A. H. Lima, M. W. van der Kamp, 2025. Insights into the Enhanced Ceftazidime Hydrolysis by Ent385 AmpC ß-Lactamase from Multiscale Simulations. ACS Catal., 15, 11739–11748, DOI: 10.1021/acscatal.5c02383.

More information on project and DTP:
https://lnkd.in/e7ZC3wFR

Applications close Oct 20th, but please contact me before applying to the DTP (by October 5th), with a draft for the text fields on the application form.

Funding details

This is a fully funded 4-year PhD position through the GW4 BioMed Doctoral Training Programme. Funding covers tuition fees and provides a stipend for living expenses. The position is not self-funded and includes support for research activities.

What's required

Applicants must have a strong background in microbiology or a related biological science. Experience or interest in computational biology, molecular dynamics, enzyme assays, or structural biology is desirable. Selection is highly competitive and managed by the GW4 BioMed DTP. Candidates should prepare a draft for the application form text fields and contact the lead supervisor before applying. No specific GPA or language requirements are mentioned, but standard PhD entry requirements for UK universities apply.

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Professors

Professor at University of Bristol

University Name
Country flag

United Kingdom

Research Interests

Microbiology

Molecular Biology

Molecular Dynamics

Computational Biology

Biomedical Engineering

Professor at School of Physics

University Name
Country flag

United Kingdom

Research Interests

Biochemistry

Biochemical Engineering

Antibiotic Resistance

Chemistry

Enzyme Engineering