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Céline Koster
Just Landed
1 days ago
PhD in cell therapy for hereditary eye diseases: A vision for the future Amsterdam UMC in Netherlands
Degree Level
PhD
Field of study
Biomedical Engineering
Funding
PhD employment contract at Amsterdam UMC Research BV for 12 months, intended to extend to a total of four years; salary scale OIO €3,217 to €4,077 gross per month for full-time employment, plus 8.3% end-of-year bonus, public transport reimbursement, mileage allowance, bike scheme, and pension accrual.
Deadline
Nov 22, 2026
Country
Netherlands
University
Amsterdam UMC
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About this position
This PhD project at Amsterdam UMC focuses on translating hereditary retinal disease biology into model systems that can support the development of new treatments. The work centers on gyrate atrophy and retinitis pigmentosa, using patient-based in vitro and in vivo models to study disease mechanisms and assess the potential of cell therapy.
You will work with patient-derived stem cells, developing and optimizing differentiation protocols for retinal cell types and tissue models. A major part of the project is to characterize how genetic and clinical patient features are reflected in the morphology, molecular profile, and function of the models, and to determine which model systems and outcome measures are most useful for evaluating new therapies.
The project also explores how stem cell-derived cells and biomaterials can be combined into transplantable constructs, with preclinical evaluation of their survival, integration, and function after transplantation. This connects model development directly to therapeutic testing and regenerative approaches for hereditary eye diseases.
You will be embedded in the Ophthalmogenetics section of Human genetics at Amsterdam UMC and work closely with clinicians from the Emma Children's Hospital, the Emma Center for Personalized Medicine, and the Department of Ophthalmology. The project is part of the Lifelong VISION consortium, linking Platform A: Model systems with Pillar 3: Cell-based therapy, and bringing together expertise in retinal model systems, stem cell biology, biomaterials, and preclinical transplantation research.
The research is positioned within a multidisciplinary environment where experimental findings are connected to clinical questions in rare hereditary disease. The opening is focused on building patient-relevant models that can help move hereditary eye disease treatments closer to the clinic.
Funding details
PhD employment contract at Amsterdam UMC Research BV for 12 months, intended to extend to a total of four years; salary scale OIO €3,217 to €4,077 gross per month for full-time employment, plus 8.3% end-of-year bonus, public transport reimbursement, mileage allowance, bike scheme, and pension accrual.
What's required
A completed Master's degree in biomedical sciences, biology, biotechnology, regenerative medicine, biomedical engineering or a related field is required. Applicants should have practical experience in experimental laboratory research and cell culture. Experience with stem cells, differentiation or complex tissue models is an advantage. The role asks for an interest in developing and characterizing disease models and in the relationship between genetic variation, cellular function and clinical characteristics, plus an interest in cell therapy and biomaterials and willingness to work with in vivo models and undertake the required training. Relevant experience and an Article 9 qualification are an advantage. Candidates should have a critical, precise and persistent research attitude, take initiative, analyze carefully and contribute ideas for solutions, communicate well in English, and enjoy collaborative work with researchers and clinicians from different disciplines. Proficiency in Dutch is an advantage. Physicians registered in the Dutch BIG register are not eligible.
How to apply
Apply through the AcademicTransfer application link. Applications are handled continuously, so submit early. If you have questions, contact Dr Céline Koster at [email protected].
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Professors
Prof. at Amsterdam UMC
Netherlands
Research Interests
Biomaterials
Clinical Translation
Cell Therapy
Medical Science
Retinal Biology
Prof. at Amsterdam UMC
Netherlands
Research Interests
Biomaterials
Regenerative Medicine
Biomedical Engineering
Biology
Cell Therapy
ApplyKite TwinLearns as you applyMake your next move.
Prepare your application
Review drafts and confirm requirements with the university.