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University of Cambridge

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PhD in Cell-Type Specific RNA Processing Defects in Neurodegeneration University of Cambridge in United Kingdom

Degree Level

PhD

Field of study

Computer Science

Funding

Competition-funded PhD project. Funding notes mention Gates US applications (round 1) closing 14 October 2026 and Cambridge Trust / Gates Cambridge (round 2) deadline 8 December 2026 for funding eligibility. Funding deadlines for Lent and Easter 2027 have passed, so self-funding would be needed for those terms if not funded through the competition.

Deadline

Dec 8, 2026

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Country

United Kingdom

University

University of Cambridge

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Keywords

Computer Science
Biology
Computational Biology
Neuropsychology
Medical Science
Rna Editing
Neurodegenerative Disease
Long-read Sequencing
Statistics
Spatial Transcriptomic

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About this position

PhD opportunity at the University of Cambridge in cell-type specific RNA processing defects in neurodegeneration.

This project, hosted by the Department of Clinical Neurosciences and linked to the Ryten Lab, focuses on how RNA processing changes in vulnerable brain cell populations contribute to neurodegenerative disease. The research is centered on Parkinson’s disease, Lewy body dementia, and Alzheimer’s disease, with emphasis on RNA splicing, transcript isoform use, RNA editing, and 3′ untranslated region usage.

The student will work with human brain transcriptomic data, including single-nucleus RNA sequencing, spatial transcriptomics, short-read RNA sequencing, and long-read RNA sequencing. The project aims to identify disease-associated RNA-processing events and RNA-binding proteins, integrate transcriptomic data with genetic and cellular information, and prioritize biomarkers or therapeutic targets. Depending on interests and skills, the work may include computational biology, development of reproducible pipelines, and experimental validation in human tissue or iPSC-derived cellular models.

Funding: This is a competition-funded PhD project. The post notes funding deadlines for Gates US and Cambridge Trust / Gates Cambridge. Applicants should ensure they apply before the relevant funding deadline and indicate all funding they are eligible for.

Location: Cambridge, United Kingdom.

Application: Register your interest via the FindAPhD listing and follow the University of Cambridge application process. Review the funding deadlines carefully before applying.

Funding details

Competition-funded PhD project. Funding notes mention Gates US applications (round 1) closing 14 October 2026 and Cambridge Trust / Gates Cambridge (round 2) deadline 8 December 2026 for funding eligibility. Funding deadlines for Lent and Easter 2027 have passed, so self-funding would be needed for those terms if not funded through the competition.

What's required

PhD only. The project is suitable for students interested in neurodegeneration, RNA biology, genomics, single-cell and spatial transcriptomics, long-read RNA sequencing, computational biology, and therapeutic target discovery. Depending on the student’s interests and skills, the project may involve computational analysis, reproducible pipeline development, and experimental validation in human tissue or iPSC-derived cellular models. Funding eligibility is tied to Cambridge funding deadlines; applicants should indicate all funding they are eligible for.

How to apply

Register your interest through the FindAPhD page and submit your application to the University of Cambridge. Make sure to indicate all funding schemes you are eligible for before the relevant funding deadlines. Check the Gates and Cambridge Trust funding pages for the round deadlines mentioned in the post.

More information can be found here

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