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University of Cambridge
Top university
3 months ago
PhD in Cell-Type Specific RNA Processing Defects in Neurodegeneration University of Cambridge in United Kingdom
Degree Level
PhD
Field of study
Computer Science
Funding
Competition-funded PhD project. Funding notes mention Gates US applications (round 1) closing 14 October 2026 and Cambridge Trust / Gates Cambridge (round 2) deadline 8 December 2026 for funding eligibility. Funding deadlines for Lent and Easter 2027 have passed, so self-funding would be needed for those terms if not funded through the competition.
Deadline
Dec 8, 2026
Country
United Kingdom
University
University of Cambridge
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About this position
PhD opportunity at the University of Cambridge in cell-type specific RNA processing defects in neurodegeneration.
This project, hosted by the Department of Clinical Neurosciences and linked to the Ryten Lab, focuses on how RNA processing changes in vulnerable brain cell populations contribute to neurodegenerative disease. The research is centered on Parkinson’s disease, Lewy body dementia, and Alzheimer’s disease, with emphasis on RNA splicing, transcript isoform use, RNA editing, and 3′ untranslated region usage.
The student will work with human brain transcriptomic data, including single-nucleus RNA sequencing, spatial transcriptomics, short-read RNA sequencing, and long-read RNA sequencing. The project aims to identify disease-associated RNA-processing events and RNA-binding proteins, integrate transcriptomic data with genetic and cellular information, and prioritize biomarkers or therapeutic targets. Depending on interests and skills, the work may include computational biology, development of reproducible pipelines, and experimental validation in human tissue or iPSC-derived cellular models.
Funding: This is a competition-funded PhD project. The post notes funding deadlines for Gates US and Cambridge Trust / Gates Cambridge. Applicants should ensure they apply before the relevant funding deadline and indicate all funding they are eligible for.
Location: Cambridge, United Kingdom.
Application: Register your interest via the FindAPhD listing and follow the University of Cambridge application process. Review the funding deadlines carefully before applying.
Funding details
Competition-funded PhD project. Funding notes mention Gates US applications (round 1) closing 14 October 2026 and Cambridge Trust / Gates Cambridge (round 2) deadline 8 December 2026 for funding eligibility. Funding deadlines for Lent and Easter 2027 have passed, so self-funding would be needed for those terms if not funded through the competition.
What's required
PhD only. The project is suitable for students interested in neurodegeneration, RNA biology, genomics, single-cell and spatial transcriptomics, long-read RNA sequencing, computational biology, and therapeutic target discovery. Depending on the student’s interests and skills, the project may involve computational analysis, reproducible pipeline development, and experimental validation in human tissue or iPSC-derived cellular models. Funding eligibility is tied to Cambridge funding deadlines; applicants should indicate all funding they are eligible for.
How to apply
Register your interest through the FindAPhD page and submit your application to the University of Cambridge. Make sure to indicate all funding schemes you are eligible for before the relevant funding deadlines. Check the Gates and Cambridge Trust funding pages for the round deadlines mentioned in the post.
Make your next move.
Prepare your application
Review drafts and confirm requirements with the university.
Make your next move.
Prepare your application
Review drafts and confirm requirements with the university.