PhD in Preclinical Human Neural Organoid and Computational AI Model Development University of Cambridge in United Kingdom

PhD opportunity at the University of Cambridge in cell-type specific RNA processing defects in neurodegeneration . This project, hosted by the Department of Clinical Neurosciences and linked to the Ryten Lab , focuses on how RNA processing changes in vulnerable brain cell populations contribute to neurodegenerative disease. The research is centered on Parkinson’s disease , Lewy body dementia , and Alzheimer’s disease , with emphasis on RNA splicing , transcript isoform use , RNA editing , and 3′...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

PhD opportunity in Oxford on RNA dysfunction in Parkinson’s disease, offered through the UK Human Functional Genomics Initiative FGx-DLA programme. The project, titled “One gene, many transcripts: decoding RNA dysfunction in Parkinson’s disease using single-cell ‘omics, CRISPR, and stem cell models” , combines single-cell genomics, bioinformatics, CRISPR-based experiments, and stem cell models to investigate how genetic variation shapes RNA regulation in disease-relevant cell types and how these...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Endoplasmic Reticulum Transport and Morphoregulation in Neuron (Patho) Physiology . This project sits at the intersection of neuroscience , neurology , cell biology , and medical science , with additional links to physics and computer science through advanced imaging and analysis. The research investigates how endoplasmic reticulum (ER) network integrity, ER morphology, and luminal transport support neu...

Beatriz Salvador Barbero is recruiting a postdoctoral researcher to join the new Cell Heterogeneity in Cancer Initiation lab at the Barts Cancer Institute, Queen Mary University of London. The CRUK-funded project investigates how cellular heterogeneity contributes to pancreatic cancer initiation . The researcher will work across complementary experimental and computationally enabled approaches, including cutting-edge transcriptomics, single-cell transcriptomics and spatial transcriptomics. The r...