PhD in Inherited Eye Diseases and Mitochondrial Genetics University of Cambridge in United Kingdom

PhD/MPhil opportunity at the University of Cambridge in the Department of Clinical Neurosciences with Prof R Horvath. This project focuses on inherited neuromuscular diseases , including mitochondrial disease and other childhood-onset neurological disorders. The research aims to identify novel disease genes , understand molecular and mutational mechanisms, and develop targeted treatments for children with disabling, progressive, often fatal conditions. Research approaches include next-generation...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Mitochondrial Genetic Determinants of Multiple Sclerosis . This project investigates how mitochondrial genetic variants influence the outcome of multiple sclerosis (MS) . The research builds on prior genome-wide association studies (GWAS) that have identified more than 200 autosomal variants associated with MS, while extending the analysis to the mitochondrial genome. Using a dedicated mitochondrial var...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on neuroinflammatory mediators in the pathophysiology of traumatic brain injury (TBI) . The project investigates how maladaptive inflammation contributes to TBI and aims to identify mechanisms leading to brain swelling, raised intracranial pressure, and neuronal injury . The research integrates protein assays in biological fluids , neuro-intensive care monitoring , and patient outcomes , making it a strong...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on cerebral small vessel disease (cSVD) , with a focus on identifying shared mechanisms and therapeutic targets across genetic and sporadic disease forms. The project will use patient-derived induced pluripotent stem cell (iPSC) models to study vascular cell phenotypes in the neurovascular unit. The research combines cellular biology , molecular biology , functional assays , and transcriptomics/omics to un...