PhD/MPhil in Identifying Novel Genes and Developing Treatments for Children with Inherited Neuromuscular Diseases University of Cambridge in United Kingdom

PhD opportunity in Inherited Eye Diseases and Mitochondrial Genetics at the University of Cambridge , Department of Clinical Neurosciences. This project sits at the intersection of neuroscience , medical science , and biology , with a strong translational focus on mitochondrial genetics , inherited eye diseases , and inherited optic neuropathies . The supervisor, Professor Patrick Yu-Wai-Man , leads research on progressive retinal ganglion cell loss, deep phenotyping, biomarker profiling, and ge...

PhD opportunity at the University of Birmingham in the lab of Sofia Ahola , Assistant Professor in the Department of Metabolism and Systems Science. The project asks why some cells tolerate mitochondrial DNA mutations while others develop severe disease, with a focus on mitochondrial dysfunction , tissue-specific disease , and the identification of therapeutic targets . The studentship is part of the newly established MRC Centre of Research Excellence in Mitochondrial Genome Therapeutics (MitoGT...

PhD opportunity at the University of Southampton on metabolic health , GLP-1 receptor agonists , and pancreas–bone crosstalk . This project asks whether bone density loss seen in people taking GLP-1 weight-loss drugs is caused by the medication itself or by weight loss and reduced skeletal loading. It also investigates possible pancreatic effects of long-term exposure, especially in people with excess pancreatic fat. You will work with micro-CT imaging of patient pancreatic tissue, human stem-ce...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

Funded DPhil/PhD opportunities are available in Therapeutic Genomics through the MRC Centre of Research Excellence in Therapeutic Genomics (MRC CoRE-TG), with projects at the University of Oxford and Newcastle University . Projects combine experimental and translational research and may involve molecular and cellular biology , genomic technologies , disease models , CRISPR , antisense oligonucleotides , computational analysis, and therapeutic development aimed at advancing genome-targeted therap...