PhD in Neuroinflammatory Mediators in the Pathophysiology of Traumatic Brain Injury University of Cambridge in United Kingdom

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on programmed axon death , SARM1 , NMNAT2 , and protein design . The project focuses on understanding the mechanism of programmed axon death, an intrinsic axonal death pathway implicated in neurodegenerative disease and injury. The work will use rational protein design to create variant forms of SARM1 or hybrid reporter constructs to study activation, stability, enzyme activity, and post-translational modi...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on retrograde mitochondrial signalling, epigenetic reprogramming, glial toxicity, and neuroinflammation in progressive multiple sclerosis . The project focuses on how mitochondrial dysfunction and mitochondrial stress trigger nuclear signalling and epigenetic changes that may drive astrocytes toward a dysfunctional disease-associated radial glia-like (DARG) phenotype. The work is strongly research-oriented...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Fluid Biomarkers of Inflammation in Frontotemporal Dementia . This project focuses on neuroscience , neurology , neuroinflammation , frontotemporal dementia , and related neurodegenerative disorders, with additional relevance to Alzheimer’s disease , biomarkers , proteomics , neuroimaging , and clinical data analysis. The research aims to characterise inflammation signatures in blood and CSF from people...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on Mitochondrial Genetic Determinants of Multiple Sclerosis . This project investigates how mitochondrial genetic variants influence the outcome of multiple sclerosis (MS) . The research builds on prior genome-wide association studies (GWAS) that have identified more than 200 autosomal variants associated with MS, while extending the analysis to the mitochondrial genome. Using a dedicated mitochondrial var...

PhD opportunity at the University of Cambridge in the Department of Clinical Neurosciences on cerebral small vessel disease (cSVD) , with a focus on identifying shared mechanisms and therapeutic targets across genetic and sporadic disease forms. The project will use patient-derived induced pluripotent stem cell (iPSC) models to study vascular cell phenotypes in the neurovascular unit. The research combines cellular biology , molecular biology , functional assays , and transcriptomics/omics to un...