PhD in The Molecular Architecture of Neurotransmission Medical Research Council (Cambridge) Laboratory of Molecular Biology in United Kingdom

PhD opportunity in pathological protein assembly in neurodegenerative diseases at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom . The project is centered on the molecular pathology of neurodegeneration, with a focus on amyloid filament formation by disease-associated proteins such as TDP-43 , annexin A11 , and TAF15 . Two PhD project directions are described. One aims to reproduce pathological protein filament structures in vitro using protein biochemist...

PhD opportunity in AMPA receptor structure and function at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . This project sits at the intersection of neuroscience , molecular biology , and structural biology , focusing on how AMPA glutamate receptors (AMPA-Rs) and their auxiliary proteins shape excitatory synaptic transmission, plasticity, and information storage in the brain. The lab aims to decode AMPAR signalling complexity from atomic structure...

PhD opportunity in mechanism of transcription-coupled splicing at the Medical Research Council Laboratory of Molecular Biology in Cambridge, United Kingdom , supervised by Dr Suyang Zhang . The project focuses on how RNA polymerase II and the spliceosome communicate during co-transcriptional splicing to ensure accurate gene expression in eukaryotic cells. The lab studies the molecular mechanisms coordinating transcription and pre-mRNA splicing in human cells, including direct interactions betwee...

PhD opportunity in DNA repair at stalled replication forks at the Medical Research Council (Cambridge), Laboratory of Molecular Biology in the United Kingdom . The project focuses on DNA repair , replication stress , and the Fanconi Anaemia (FA) pathway , with particular attention to how cells respond to DNA crosslinks and stalled replication forks. The research aims to understand the molecular mechanisms of crosslink repair and the role of the FANCD2-FANCI heterodimer and FA core complex in mai...

PhD opportunity in Protein Aggregates and Neurodegeneration at the Medical Research Council (Cambridge), Laboratory of Molecular Biology, with Dr H McMahon. This project explores how protein aggregates accumulate, become toxic to brain cells, and spread in neurodegenerative disease. Two related PhD projects are available in the McMahon group. One focuses on aggregate uptake mechanisms , including Aggregation-Dependent Endocytosis, receptor identification, aggregate size effects, and ways to prev...