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Barbara Uszczyńska-Ratajczak

1 year ago

PhD Position: Advancing Single-Molecule RNA Sequencing and Structure Analysis for Custom Genomic Regions University of Udine in Italy

Degree Level

PhD

Field of study

Molecular Biology

Funding

Funded PhD Project (Students Worldwide)

Deadline

Expired

Country flag

Country

Italy

University

University of Udine

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Keywords

Molecular Biology
Biomedical Engineering
Biotechnology
Biology
Health Science
Rna Biology
Liquid Biopsy
Cancer Diagnosis
Sampling Methods
Rna-seq
Alternative Splicing
Genomic
Non-coding Rna
Bioinformatic
Transcriptomic

About this position

This PhD project, hosted at the Institute of Bioorganic Chemistry, Polish Academy of Sciences in Poland, focuses on advancing single-molecule RNA sequencing and structure analysis for custom genomic regions. The research addresses the limitations of conventional RNA sequencing, which often fails to capture the full diversity of RNA species, particularly those with complex structures, low abundance, or extensive alternative splicing. The project aims to develop an integrated strategy combining targeted enrichment, adaptive sampling, and structural analysis to achieve precise single-molecule resolution of alternative splicing, RNA folding, and chemical modifications. These methods will be applied to study long noncoding RNAs and detect cancer biomarkers in liquid biopsy samples, with broad applications in transcriptomics, cancer diagnostics, and RNA therapeutics.

The successful candidate will join the cobRNA Lab, a vibrant and multidisciplinary team dedicated to developing innovative genomic and bioinformatic approaches for the identification and functional characterization of long noncoding RNAs across vertebrate genomes. The lab fosters a collaborative and inclusive environment, actively participating in international initiatives such as GENCODE and organizing scientific events like the EMBO Workshop “Non Coding RNA Medicine.” The project includes secondments to collaborating groups in Ireland and Spain, requiring a willingness to travel and spend time abroad. Applicants must hold a Master’s degree in Biology, Biotechnology, or a related field, and must not already possess a doctoral degree.

Required skills include basic knowledge of RNA sequencing, experience with human cell line culture, and proficiency in English. Familiarity with Linux and bioinformatics is desirable. The position is funded as part of the INT2ACT Doctoral Network, with details on stipend and benefits available via the recruitment web page. The application deadline is January 31, 2026.

For more information, candidates can contact Prof. Barbara Uszczyńska-Ratajczak or visit the INT2ACT website.

Funding details

Funded PhD Project (Students Worldwide)

What's required

Applicants must hold a Master’s degree in Biology, Biotechnology, or a related discipline. They must not already possess a doctoral degree. Candidates should have basic knowledge of RNA sequencing and experience with human cell line culture. Familiarity with the Linux command line and basic bioinformatics is desirable. Proficiency in English is essential, demonstrated by an English language certificate (IELTS, TOEFL, or Cambridge English), unless exempted by nationality or prior degree. The mobility rule applies: researchers must not have resided or carried out their main activity in Poland for more than 12 months in the 36 months immediately before recruitment.

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Professors

Professor at INT2ACT

University Name
Country flag

Italy

Research Interests

Cancer Diagnosis

Rna-seq

Sampling Methods

Rna Biology

Biology

Dr. at INT2ACT

University Name
Country flag

Italy

Research Interests

Organic Chemistry

Tissue Engineering

Health Science

Biomedical Engineering

Biotechnology

Dr. at INT2ACT

University Name
Country flag

Italy

Research Interests

Biomedical Engineering

Transcriptomic

Biology

Molecular Biology

Rna Biology