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Outi Supponen

11 months ago

PhD student position in fluid dynamics and optics for biomedical applications ETH Zürich in Switzerland

Degree Level

PhD

Field of study

Biomedical Engineering

Funding

Available

Deadline

Aug 29, 2026

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Country

Switzerland

University

ETH Zürich

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Keywords

Biomedical Engineering
Mechanical Engineering
Drug Delivery
Biophysics
Optics
Fluid Mechanics
Preclinical Research
Particle Dynamics
Bubble Dynamics
High-speed Imaging
Acoustic Physics
Permeability Analysis
Blood-brain Barrier
Laboratory Experimentation
Optoacoustics
Physics

About this position

This PhD position at ETH Zürich is part of a collaborative project between the Multiphase Fluid Dynamics group (Prof. Outi Supponen) at the Institute of Fluid Dynamics and the Functional and Molecular Imaging group (Prof. Razansky) at the Institute of Biomedical Engineering. The research centers on developing a novel, laser-based technique for precise, controlled opening of the blood-brain barrier (BBBO) to enable targeted drug delivery for neurological diseases such as Alzheimer’s and brain tumors. The project aims to overcome the limitations of current methods, like focused ultrasound with microbubbles, by using laser-induced bubble generation to create temporary, safe openings in the BBB, allowing therapeutic agents to reach the brain with high precision and minimal side effects. The selected PhD student will focus on experimental research involving modeling and high-speed imaging to optimize bubble generation and control, as well as studying particle dynamics and cell interactions using in-vitro models. The work will also include validation in preclinical models, leveraging advanced imaging technologies such as fluorescence and optoacoustic imaging. The expected outcome is a laser-based platform for BBBO that can be translated into clinical applications, advancing both scientific understanding and therapeutic options for neurological disorders. The position offers access to state-of-the-art facilities, a collaborative and inclusive research environment, and numerous benefits including public transport, sports, childcare, and pension plans. Applicants should have a Master’s degree in a relevant field, strong interest in experimental research, and be ready to work in an international, interdisciplinary team. The application deadline is August 29, 2025, with a negotiable start date in early 2026 or fall 2025. Applications must be submitted via the ETH Zurich online portal, including a motivation letter, CV, transcripts, and references. For further information, candidates may contact Prof. Outi Supponen ([email protected]) for group-specific queries, but not for application submission.

Funding details

Available

What's required

Applicants must hold a Master's degree in biomedical, mechanical or aeronautical engineering, physics, material science, or a related field. Candidates should be curiosity-driven, creative, open-minded, independent, and possess good communication skills, fluency in English, and a willingness to work as part of an international team. Strong interest in experimental fluid mechanics, optics, biomedical engineering, or similar is required. Experience in experimental research is advantageous but not mandatory. Ability to work with people from different areas of expertise is important.

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Professors

Professor at ETH Zürich

University Name
Country flag

Switzerland

Research Interests

Fluid Mechanics

Polymer Physics

Cavitation

Acoustofluidics

Shock Physics