Publisher
source

University of Exeter

Just Landed

PhD Studentship: Editing the Alzheimer’s Epigenome: From Human Brain Variation to Functional Mechanisms University of Exeter in United Kingdom

Degree Level

PhD

Field of study

Computer Science

Funding

Available

Deadline

Jan 5, 2027

Country flag

Country

United Kingdom

University

University of Exeter

Apply for this position

Keywords

Computer Science
Biology
Functional Genomics
Alzheimer's Disease
Neuropsychology
Medical Science
Transcriptional Regulation
Omics
Neurodegenerative Disease
Epigenetic
Statistics
Microglia
Bioinformatic

Suggested positions

Publisher
source

University of Oxford

Country flag

United Kingdom

PhD opportunity in Oxford on RNA dysfunction in Parkinson’s disease, offered through the UK Human Functional Genomics Initiative FGx-DLA programme. The project, titled “One gene, many transcripts: decoding RNA dysfunction in Parkinson’s disease using single-cell ‘omics, CRISPR, and stem cell models” , combines single-cell genomics, bioinformatics, CRISPR-based experiments, and stem cell models to investigate how genetic variation shapes RNA regulation in disease-relevant cell types and how these...

Computer Science
Biology
Parkinson's Disease
+5 more

4 days ago

Publisher
source

Ohio State University

Country flag

United States

Postdoctoral Scholar in Neurology at The Ohio State University The Department of Neurology at The Ohio State University is advertising an immediate-start postdoctoral position in the Desplats Lab. The project investigates how altered epigenetic mechanisms and circadian desynchrony contribute to adult neurodegenerative disorders and accelerated aging. Research themes include neurodegeneration, epigenetics, circadian biology, multi-omics, transcriptional analysis, spatial omics, CRISPR, Cre/flox t...

Computer Science
Neurology
Biology
+9 more

2 weeks ago

Publisher
source

Washington University in St. Louis

Country flag

United States

Postdoctoral Research Associate in Proteomics and Multiomics in Neurodegeneration at Washington University in St. Louis (WashU Medicine), Department of Psychiatry / NeuroGenomics and Informatics Center. The Cruchaga lab is recruiting a fully funded postdoctoral fellow to study Alzheimer’s disease and other neurodegenerative diseases using proteomics , multi-omics , and integrative analyses of brain, CSF, and blood datasets. The lab works on transcriptomics, proteomics, metabolomics, genetics, bi...

Computer Science
Biomedical Engineering
Biology
+10 more

6 days ago

Publisher
source

Archana Sharma-Oates

University of Birmingham

Country flag

United Kingdom

Fully funded PhD opportunity at the University of Birmingham within the Midlands Integrative Biosciences Training Partnership (MIBTP) , a BBSRC-funded doctoral training partnership. The project is titled “A multi-omics approach to characterise brain-specific biological ageing” and is supervised by Archana Sharma-Oates in collaboration with Vinton Cheng . The research focuses on how the brain ages differently from the rest of the body, using multi-omics data integration , genomic data analysis , ...

Computer Science
Biology
Computational Biology
+8 more

2 weeks ago

Publisher
source

Colorado State University

Country flag

United States

Colorado State University is recruiting two postdoctoral fellows in statistical genetics and genomics . The position is based in the Department of Statistics and involves close collaboration with Dr. Gao Wang and his research team in the Department of Neurology at Columbia University. The research program focuses on statistical methodology , functional genomics , human genetic and multi-omic data , and neuroscience , including NIH-funded work on nonlinear and context-dependent genetic regulation...

Computer Science
Biomedical Engineering
Biology
+8 more

1 week ago

About this position

[Home tuition fees plus a Doctoral Stipend for up to 4 years.]

PhD Studentship at the University of Exeter in Editing the Alzheimer’s Epigenome: From Human Brain Variation to Functional Mechanisms.

This studentship addresses a major question in Alzheimer’s disease research: which epigenetic changes observed in human brain actually alter gene regulation and contribute to disease biology. The project builds on cell-type-specific epigenomic datasets generated from human post-mortem brain using fluorescence-activated nuclei sorting (FANS), including DNA methylation, ATAC-seq chromatin accessibility, and H3K27ac profiling. By integrating these datasets with gene expression, genetic association, and regulatory annotations, the student will prioritise Alzheimer’s-associated loci with strong evidence for functional regulatory activity in promoters and enhancers.

The project combines multi-omic computational analysis with experimental validation. Selected candidate loci will be investigated using targeted CRISPR epigenome editing, including dCas9-based methylation, demethylation, or chromatin remodelling approaches in relevant cell lines and hiPSC-derived neural models such as cortical neurons and microglia. The work will then assess how perturbing these loci affects gene expression, epigenetic state, and cellular phenotype, using assays such as bisulfite pyrosequencing and follow-on transcriptomic, methylomic, and chromatin-accessibility profiling for top candidates.

The studentship is highly interdisciplinary and is designed for a student interested in disease epigenomics, functional genomics, stem-cell models, and computational biology. Training will include multi-omic data integration, reproducible bioinformatics, experimental epigenomics, cell culture, epigenome editing, and functional assays. The project also benefits from established FANS and epigenomic pipelines and access to hiPSC-derived neurodegeneration models and targeted DNA methylation editing expertise across Exeter and collaborating teams.

Funding covers Home tuition fees and a Doctoral Stipend for up to 4 years. The deadline is 05 Jan. Applicants should review the University of Exeter funding page and follow the application instructions there.

Funding details

Available

What's required

Applicants should be interested in interdisciplinary research spanning human disease epigenomics, computational biology, stem-cell models and CRISPR-based functional genomics. The project would suit candidates with strengths or interest in multi-omic data integration, reproducible bioinformatics, experimental epigenomics, cell culture, epigenome editing and functional assays. No specific degree classification, language test, or prior experience is explicitly stated in the posting.

How to apply

Apply via the University of Exeter funding/application link provided. Submit the application before the deadline. Check the advert and linked funding page for any additional documentation or eligibility details.

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts and confirm requirements with the university.