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Alexandre Slater

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11 months ago

PhD Studentship: The Role of O-glycosylation of the Stalk Region of the Immunoglobulin Receptor GPVI University of Birmingham in United Kingdom

Degree Level

PhD

Field of study

Biochemistry

Funding

Available

Deadline

Expired

Country flag

Country

United Kingdom

University

University of Birmingham

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Keywords

Biochemistry
Biology
Health Science
Mutagenesis
Mass Spectrometry
Glycobiology
Super-resolution Microscopy
Chromatography
Nanomedicine
Receptor Biology
Platelet Biology
Cell Culture Techniques
Anticoagulation
Biomedicine

About this position

[BBSRC-funded PhD studentship via the Midlands Integrated Biosciences Training Partnership (MIBTP), in partnership with University of Warwick, Aston University, Harper Adams University, Coventry University, and University of Leicester.] This PhD studentship at the University of Birmingham, funded by the BBSRC through the Midlands Integrated Biosciences Training Partnership (MIBTP), investigates the role of O-glycosylation in the stalk region of the immunoglobulin receptor GPVI, a key platelet receptor involved in thrombosis. GPVI is a major signalling receptor for collagen on platelets, and its inhibition is a promising strategy for anti-thrombotic therapy with minimal impact on haemostasis. The project aims to map the O-glycosylation sites on the GPVI stalk and determine their functional significance in platelet signalling. Students will use site-directed mutagenesis to generate GPVI constructs lacking specific glycosylation sites, followed by signalling assays to assess their impact.

Super resolution microscopy will be employed to study the distribution of GPVI on the cell membrane, and nanobodies will be raised against the stalk region to evaluate their effects on GPVI expression and signalling in both transfected cell lines and platelets. The research is supervised by Dr Alexandre Slater, who specializes in platelet receptor structure, and Prof Steve Watson, an expert in platelet signalling, both based in the Birmingham Platelet group within the Department of Cardiovascular Sciences. The project offers training in a range of advanced techniques, including mammalian cell culture, site-directed mutagenesis, nanobody characterisation, size exclusion chromatography, super resolution microscopy, mass-spectrometry, and platelet biology. The ultimate goal is to identify and develop potent nanobodies as novel anti-platelet agents targeting thrombosis.

Applicants should have a strong background in biomedicine, biochemistry, or a related field. The studentship covers tuition and stipend, and is open to candidates who meet the eligibility criteria. The application deadline is 27 November 2025. Interested candidates should prepare a CV, covering letter, references, degree certificates, and evidence of English proficiency if required, and apply via the University of Birmingham's online portal.

Informal enquiries can be directed to Dr Alexandre Slater or Prof Steve Watson. For more information, visit the MIBTP and University of Birmingham programme pages.

Funding details

Available

What's required

Applicants should have a strong background in either biomedicine, biochemistry, or a related topic. A detailed CV, names and addresses of two referees, a covering letter highlighting research experience and capabilities, copies of degree certificates with transcripts, and evidence of English language proficiency (if applicable) are required. No specific GPA or language test scores are mentioned, but proficiency in English is expected.

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Professors

Dr at University of Birmingham

University Name
Country flag

United Kingdom

Research Interests

Biochemistry

Polymer Physics

Platelet Biology

Hemostasis

Endothelial Cell Biology

Prof at University of Birmingham

University Name
Country flag

United Kingdom

Research Interests

Biochemistry

Glycobiology

Mutagenesis

Anticoagulation

Platelet Biology