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Yale University

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Postdoctoral Position in Cancer Diagnostics and Epigenomics at Yale Yale University in United States

Degree Level

Postdoc

Field of study

Chemistry

Funding

Year 1 compensation is $68,500. Postdoctoral associates and fellows are paid monthly on the last business day of each month. Salary increases, when applicable, are provided at reappointment, with compensation discussions held with the faculty mentor during the reappointment process.

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Country

United States

University

Yale University

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Keywords

Chemistry
Cancer Biology
Biology
Computational Biology
Sequencing Technology
Medical Science
Cancer Diagnosis
Nucleic Acid Chemistry
Epigenetic
Bioinformatic

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About this position

The Patel Lab at Yale School of Medicine and Yale Cancer Center is offering a postdoctoral research opportunity in cancer diagnostics and epigenomics within Yale’s Department of Therapeutic Radiology in New Haven, Connecticut.

The laboratory develops blood-based tests for early cancer detection, minimal residual disease assessment, and monitoring treatment response and recurrence. The research combines nucleic acid biochemistry, sequencing technologies, and computational analysis to measure rare cancer-associated signals in cell-free DNA.

A major research direction is the development and application of methods to capture densely methylated DNA fragments across the genome, particularly at CpG islands and gene promoters. These approaches support cancer detection and monitoring without requiring prior analysis of tumor tissue. Projects may address assay sensitivity and reproducibility, discrimination of tumor-derived signals from normal tissue background, and evaluation of methylation biomarkers in longitudinal patient samples.

The lab also investigates relationships between DNA methylation, Polycomb-associated chromatin regulation, tumor heterogeneity, and treatment resistance. The postdoctoral researcher will have opportunities to lead projects, develop new methods, and collaborate with scientists and clinicians while building expertise in experimental design, quantitative analysis, scientific writing, and an independent research direction.

Mentorship will be provided by Dr. Abhijit Patel in a research environment spanning molecular biology, cancer biology, epigenetics, sequencing, and computational analysis.

Funding details

Year 1 compensation is $68,500. Postdoctoral associates and fellows are paid monthly on the last business day of each month. Salary increases, when applicable, are provided at reappointment, with compensation discussions held with the faculty mentor during the reappointment process.

What's required

Candidates must hold a Ph.D., M.D., or equivalent doctoral degree by the start of the appointment and demonstrate a strong research record, scientific curiosity, and the ability to work independently and collaboratively. Applicants may come from molecular biology, biochemistry, chemistry, cancer biology, epigenetics, bioinformatics, or related fields. Valuable experience includes nucleic acid assay development, enzymology, PCR or quantitative PCR, low-input DNA, sequencing library preparation, DNA methylation profiling, liquid biopsy research, genomic or epigenomic data analysis, Python or R, statistical analysis, and reproducible sequencing workflows in Linux. Experience with every listed technique is not required.

How to apply

Email a CV and brief cover letter describing research interests and relevant experience to [email protected]. Use the subject line “Patel Lab Postdoctoral Application.” Selected candidates will be asked to provide reference contacts; interviews may be conducted in person or via Zoom.

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