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University of Gothenburg

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Postdoctoral Position in Medicinal Chemistry University of Gothenburg in Sweden

Degree Level

Postdoc

Field of study

Chemistry

Funding

Available

Deadline

Dec 2, 2026

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Country

Sweden

University

University of Gothenburg

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Keywords

Chemistry
Biology
Peptide Chemistry
Molecular Modeling
Chemical Biology
Medical Science
Pharmacy
Nmr Spectroscopy
Pharmaceutical Chemistry
Structure-activity Relationship
Natural Product
Tuberculosi
Pharmacokinetic

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About this position

KlahnLab at the University of Gothenburg is offering a postdoctoral position in organic and medicinal chemistry focused on the development of macrocyclic peptide derivatives as clinical drug candidates for tuberculosis.

The project aims to retain strong activity against Mycobacterium tuberculosis while reducing unwanted inhibition of a human off-target protein. The work is embedded in an international research environment within the Department of Chemistry and Molecular Biology, where the broader research and teaching profile spans chemical sciences and molecular life sciences.

The successful candidate will join the Division of Organic and Medicinal Chemistry at the University of Gothenburg and work in close collaboration with Forschungszentrum Borstel in Germany as well as other specialized external partners. The project combines synthetic chemistry, compound design, characterization, and interdisciplinary interaction across a drug-discovery workflow.

Research tasks include planning and carrying out the synthesis of macrocyclic peptide derivatives derived from a natural product, with emphasis on solid-phase peptide synthesis, building block preparation, purification, and analytical characterization using techniques such as HPLC-MS and NMR. The postdoc will also contribute to design and optimization of compounds informed by structure-activity relationships and by biological and pharmacokinetic profiling.

The role includes documenting and analysing results, contributing to publications and presentations, and helping plan subsequent synthesis cycles. Molecular modelling may also be part of the collaboration with other project members.

The position is based at Natrium, Medicinareberget, Gothenburg, in an international and interdisciplinary research environment.

Funding details

Available

What's required

Eligibility requires a PhD or an equivalent foreign degree by the appointment decision date; candidates are preferably within three years of the PhD deadline, unless special reasons apply. A doctorate in organic chemistry, medicinal chemistry, chemical biology, or a closely related field is required, as is a master's degree in one of those areas. Applicants should have documented substantial practical experience in advanced organic synthesis and solid-phase peptide synthesis, extensive experience in purification and structural characterization of synthesized compounds such as chromatography, HPLC-MS and NMR, very good spoken and written English, and the ability to plan and carry out experimental research independently while collaborating in interdisciplinary projects. Meritorious experience includes cyclic peptide or natural-product-based drug candidate synthesis and modification, medicinal chemistry, SAR-driven optimization and design-make-test-analyze workflows, molecular docking or other structure-guided modelling, pharmacokinetics/DMPK and antibacterial drug development, and documented publication and international collaboration experience.

How to apply

Apply through the University of Gothenburg recruitment portal by clicking the Apply button. Prepare the application in English and ensure it is complete before the deadline. Include a CV with publication list, a brief description of previous research and future interests, contact details for at least two referees, and copies of your PhD certificate and any other supporting documents.

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