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University of North Carolina at Chapel Hill

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Postdoctoral Research Associate in Tumor NLRP3 Inflammasome, Immune Evasion, Dormancy, and Metastatic Progression University of North Carolina at Chapel Hill in United States

Degree Level

Postdoc

Field of study

Cancer Biology

Funding

This is a full-time, temporary 12-month postdoctoral appointment. The hiring range is dependent on experience or qualifications. UNC-Chapel Hill offers postdocs comprehensive medical and vision coverage, paid leave, and additional benefits and professional-development services; no specific salary or stipend amount is stated.

Deadline

Nov 30, 2026

Country flag

Country

United States

University

University of North Carolina at Chapel Hill

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Keywords

Cancer Biology
Biology
Medical Science
Metastasis
Rna-seq
Tumor Immunology
Spatial Transcriptomic

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About this position

The University of North Carolina at Chapel Hill is recruiting a full-time Postdoctoral Research Associate in the Lineberger Comprehensive Cancer Center and UNC School of Medicine. The position is based in Chapel Hill, North Carolina, United States, and is expected to last 12 months.

The project examines how the tumor-intrinsic NLRP3 inflammasome contributes to immune evasion during tumor dormancy, treatment-resistant persistor cell development, tumor relapse, and metastatic progression. Research will combine ex vivo tumor–T-cell co-culture assays, in vivo tumor models, and tumor clinical specimens.

Methods may include CRISPR/Cas9-targeted gene deletion, microbead and FACS cell purification, flow cytometry, Western blotting, qRT-PCR, ELISA, RNA-seq, single-cell RNA-seq, micro-CT imaging, immunohistochemistry, fluorescence in situ hybridization, proximity ligation assays, and potentially spatial transcriptomics.

A PhD is required. Competitive applicants should have experience with mouse tumor models and tissue culture, plus familiarity with flow cytometry and immunohistochemistry. Experience with RNA-seq transcriptional analysis and CRISPR/Cas9 is preferred. UNC postdoctoral benefits include comprehensive medical and vision coverage, paid leave, and professional-development services. The application deadline is November 30, 2026.

Funding details

This is a full-time, temporary 12-month postdoctoral appointment. The hiring range is dependent on experience or qualifications. UNC-Chapel Hill offers postdocs comprehensive medical and vision coverage, paid leave, and additional benefits and professional-development services; no specific salary or stipend amount is stated.

What's required

A PhD is required. Competitive applicants should have experience with mouse tumor model studies and tissue culture, and familiarity with flow cytometry and immunohistochemistry. Prior experience conducting and analyzing RNA-seq transcriptional analysis and using CRISPR/Cas9 is preferred. Required application materials include a curriculum vitae or resume; a cover letter and list of references are optional.

How to apply

Apply online through the UNC PeopleAdmin posting by the November 30, 2026 deadline. Submit a curriculum vitae or resume; a cover letter and list of references may also be included.

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